Recombinant Human DNA-binding protein RFXANK (RFXANK)

中文名稱：

人RFXANK重組蛋白
貨號：

CSB-YP019617HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RFXANK重組蛋白
貨號：

CSB-EP019617HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RFXANK重組蛋白
貨號：

CSB-EP019617HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RFXANK重組蛋白
貨號：

CSB-BP019617HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RFXANK重組蛋白
貨號：

CSB-MP019617HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RFXANK
Uniprot No.：

O14593
別名：

ANKRA1; Ankyrin repeat containing regulatory factor X associated protein; Ankyrin repeat family A protein 1; BLS; DNA-binding protein RFXANK; F14150_1; MGC138628; Regulatory factor X associated ankyrin containing protein; Regulatory factor X subunit B; Regulatory factor X, ankyrin repeat containing; Regulatory factor X-associated ankyrin-containing protein; RFX Bdelta4; RFX-B; RFXANK; RFXB; RFXB delta 4; RFXK_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-260
氨基酸序列

MELTQPAEDL IQTQQTPASE LGDPEDPGEE AADGSDTVVL SLFPCTPEPV NPEPDASVSS PQAGSSLKHS TTLTNRQRGN EVSALPATLD SLSIHQLAAQ GELDQLKEHL RKGDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1.; Isoform 2 is not involved in the positive regulation of MHC class II genes.
基因功能參考文獻：
1. mutation results in Bare Lymphocyte Syndrome, Type 2 in a child of Mexican descent PMID: 26634365
2. genetic, clinical, and immunologic features of 35 patients from 30 unrelated kindreds from North Africa sharing the same RFXANK founder mutation, a 26-bp deletion called I5E6-25_I5E6 + 1) PMID: 21908431
3. Findings confirm the association between the high frequency of the combined immunodeficiency and the defect in MHC class II expression and provides strong evidence for a founder effect of the 752delG26 mutation in the North African population. PMID: 20414676
4. Low levels of RFX-B are found in macrophages of colorectal cancer patients, partly explaining immunodeficiency in cancer. PMID: 11836625
5. in vivo effects of mutations on the expression of the RFXANK RNA and protein PMID: 12618906
6. ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression PMID: 15964851
7. analysis of RFXANK domains and function PMID: 16166641
8. RFXAP and RFXB have roles in relieving autoinhibition of RFX5 PMID: 18723135
顯示更多

收起更多
相關疾病：

Bare lymphocyte syndrome 2 (BLS2)
亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 9987

OMIM: 209920

KEGG: hsa:8625

STRING: 9606.ENSP00000305071

UniGene: Hs.153629