Recombinant Human Cyclin-O (CCNO)

中文名稱：

Recombinant Human Cyclin-O(CCNO)
貨號：

CSB-YP004831HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cyclin-O(CCNO)
貨號：

CSB-EP004831HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cyclin-O(CCNO)
貨號：

CSB-EP004831HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cyclin-O(CCNO)
貨號：

CSB-BP004831HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cyclin-O(CCNO)
貨號：

CSB-MP004831HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CCNO
Uniprot No.：

P22674
別名：

CCNO; CCNO_HUMAN; CCNU; Cyclin domain containing; Cyclin like uracil DNA glycosylase; Cyclin O; Cyclin U; Cyclin-O; DGU; EC 3.2.2.; UDG2; UNG2; Uracil DNA glycolylase 2; Uracil DNA glycosylase cyclin like
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-350
氨基酸序列

MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE ALARQPQVTA ESRCKLLSWL IPVHRQFGLS FESLCLTVNT LDRFLTTTPV AADCFQLLGV TSLLIACKQV EVHPPRVKQL LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF THARVEAGQA EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
基因功能參考文獻：
1. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (cyclin U) complex. PMID: 27571178
2. CCNO is mutated more frequently than expected from the rare previous clinical case reports, leads to severe clinical manifestations, and should therefore be considered an important differential diagnosis of mucociliary clearance disorders. PMID: 26777464
3. CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia PMID: 24747639
4. This publication corrected the mistaken attribution of uracil DNA glycosylase activity to this gene. PMID: 8419333
5. This publication initially attributed 'uracil-DNA glycosylase' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin protein family. PMID: 2001396
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相關疾病：

Ciliary dyskinesia, primary, 29 (CILD29)
亞細胞定位：

Cytoplasm. Nucleus, nucleolus.
蛋白家族：

Cyclin family
組織特異性：

Present in respiratory cells (at protein level).
數據庫鏈接：

HGNC: 18576

OMIM: 607752

KEGG: hsa:10309

STRING: 9606.ENSP00000282572

UniGene: Hs.3041