Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

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中文名稱：

Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1(CAMK2N1)
品名簡稱：

Recombinant Human CAMK2N1 protein
貨號：

CSB-EP004469HU
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

CAMK2N1
Uniprot No.：

Q7Z7J9
別名：

CAMK2N1Calcium/calmodulin-dependent protein kinase II inhibitor 1; CaMKII inhibitory protein alpha; CaMKIIN-alpha
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

25.6 kDa
表達區域：

1-78aa
氨基酸序列

MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRPPKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-Trx-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer，50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Potent and specific inhibitor of CaM-kinase II (CAMK2).
基因功能參考文獻：
1. CAMK2N1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
2. Hypermethylation of RUNX3/CAMK2N1 is associated with poor clinical outcome in Type II EOC, also after macroscopic complete resection. PMID: 26175272
3. contributes to prostate cancer growth and survival through androgen receptor-dependent signaling PMID: 25296973
4. Analyses suggest that CAMK2N1 plays a tumor suppressive role in prostate cancer cells. Reduced CAMK2N1 expression correlates to human prostate cancer progression and predicts poor clinical outcome. PMID: 25003983
5. hCaMKIINalpha suppresses tumor growth by inducing cell cycle arrest via p27 stabilization PMID: 18305109
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亞細胞定位：

Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density.
蛋白家族：

CAMK2N family
組織特異性：

Widely expressed. Nor detected in skeletal muscle.
數據庫鏈接：

HGNC: 24190

OMIM: 614986

KEGG: hsa:55450

UniGene: Hs.731383