Recombinant Human C-type mannose receptor 2 (MRC2), partial

中文名稱：

人MRC2重組蛋白
貨號：

CSB-YP871380HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MRC2重組蛋白
貨號：

CSB-EP871380HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MRC2重組蛋白
貨號：

CSB-EP871380HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MRC2重組蛋白
貨號：

CSB-BP871380HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MRC2重組蛋白
貨號：

CSB-MP871380HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MRC2
Uniprot No.：

Q9UBG0
別名：

C-type lectin domain family 13 member E; C-type mannose receptor 2; CD 280; CD280; CD280 antigen; CLEC 13E; CLEC13E; ENDO 180; ENDO180; Endocytic receptor (macrophage mannose receptor family); Endocytic receptor 180; FLJ35911; KIAA0709; Macrophage mannose receptor 2; Mannose receptor C type 2; MRC 2; MRC2; MRC2_HUMAN; UPAR-associated protein; UPARAP; Urokinase plasminogen activator receptor associated protein; Urokinase receptor associated protein; Urokinase receptor-associated protein; Urokinase-type plasminogen activator receptor-associated protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
基因功能參考文獻：
1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). PMID: 29061505
2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family PMID: 27247422
3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement. PMID: 26527274
4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. PMID: 26284904
5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma PMID: 26466547
6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. PMID: 25381222
7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. PMID: 25408555
8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid PMID: 24161566
9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. PMID: 23433549
10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. PMID: 22072289
11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. PMID: 21768090
12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement PMID: 20845060
13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion PMID: 20339555
14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. PMID: 19861500
15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor PMID: 11903048
16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes PMID: 12068012
17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. PMID: 12244146
18. characterization of the monosaccharide binding sites PMID: 12399458
19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor. PMID: 12645947
20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass. PMID: 12952933
21. Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis PMID: 12972549
22. Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. PMID: 17189524
23. To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. PMID: 17974964
24. By using cell isolates from uPARAP deficient mice, it is demonstrated that uPARAP is a collagen receptor. Thus uPARAP deficient fibroblasts can not internalize collagen and show a reduced adhesion/migration on collagen surfaces PMID: 12668656
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
數據庫鏈接：

HGNC: 16875

OMIM: 612264

KEGG: hsa:9902

STRING: 9606.ENSP00000307513

UniGene: Hs.7835