Recombinant Human C-type lectin domain family 4 member G (CLEC4G), partial

中文名稱：

Recombinant Human C-type lectin domain family 4 member G (CLEC4G), partial
品名簡稱：

Recombinant Human CLEC4G protein, partial
貨號：

CSB-MP744269HU1
說明書：

MSDS Datasheet
規格：

￥1128
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

CLEC4G
Uniprot No.：

Q6UXB4
別名：

Liver and lymph node sinusoidal endothelial cell C-type lectin
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

52.9 kDa
表達區域：

55-293aa
氨基酸序列

KASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal hFc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.
基因功能參考文獻：
1. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. PMID: 24623090
2. The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation. PMID: 22637699
3. The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2+) and N-acetylglucosamine. PMID: 22711492
4. Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry. PMID: 22156524
5. The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction. PMID: 21257728
6. The interaction between CD44 & LSECtin is dependent on protein-glycan recognition. CD44 is the 1st identified endogenous ligand of LSECtin, & similarly, LSECtin is a novel ligand of CD44. PMID: 20127679
7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
8. results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor PMID: 14711836
9. LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization PMID: 17339424
10. Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins. PMID: 18083206
11. LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. PMID: 19111020
12. Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response. PMID: 19632227
13. Observational study of gene-disease association. (HuGE Navigator) PMID: 18697825
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein.
組織特異性：

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).
數據庫鏈接：

HGNC: 24591

OMIM: 616256

KEGG: hsa:339390

STRING: 9606.ENSP00000327599

UniGene: Hs.220649