Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC1S3)

中文名稱：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC1S3)
貨號：

CSB-YP747525HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC1S3)
貨號：

CSB-EP747525HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC1S3)
貨號：

CSB-EP747525HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC1S3)
貨號：

CSB-BP747525HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC1S3)
貨號：

CSB-MP747525HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

BLOC1S3
Uniprot No.：

Q6QNY0
別名：

Biogenesis of lysosomal organelles complex 1 subunit 3; Biogenesis of lysosome-related organelles complex 1 subunit 3; BL1S3_HUMAN; BLOC-1 subunit 3; Bloc1s3; BLOS3; HPS8; reduced pigmentation; mouse; homolog of; RP
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-202
氨基酸序列

MASQGRRRRP LRRPETVVPG EATETDSERS ASSSEEEELY LGPSGPTRGR PTGLRVAGEA AETDSEPEPE PEPTAAPRDL PPLVVQRESA EEAWGTEEAP APAPARSLLQ LRLAESQARL DHDVAAAVSG VYRRAGRDVA ALASRLAAAQ AAGLAAAHSV RLARGDLCAL AERLDIVAGC RLLPDIRGVP GTEPEKDPGP RA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
基因功能參考文獻：
1. Observational study, meta-analysis, and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20460622
2. A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8). PMID: 16385460
相關疾病：

Hermansky-Pudlak syndrome 8 (HPS8)
亞細胞定位：

Cytoplasm.
蛋白家族：

BLOC1S3 family
數據庫鏈接：

HGNC: 20914

OMIM: 609762

KEGG: hsa:388552

STRING: 9606.ENSP00000393840

UniGene: Hs.103902