Recombinant Human Amiloride-sensitive sodium channel subunit gamma (SCNN1G), partial

中文名稱：

人SCNN1G重組蛋白
貨號：

CSB-YP020851HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SCNN1G重組蛋白
貨號：

CSB-EP020851HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SCNN1G重組蛋白
貨號：

CSB-EP020851HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SCNN1G重組蛋白
貨號：

CSB-BP020851HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SCNN1G重組蛋白
貨號：

CSB-MP020851HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SCNN1G
Uniprot No.：

P51170
別名：

Amiloride sensitive epithelial sodium channel gamma subunit; Amiloride sensitive sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma; BESC3; ENaC gamma subunit; ENaCG; ENaCgamma; Epithelial Na(+) channel subunit gamma; Epithelial Na+ channel subunit gamma; Gamma ENaC; Gamma NaCH; Gamma-ENaC; Gamma-NaCH; Nonvoltage gated sodium channel 1 subunit gamma; Nonvoltage-gated sodium channel 1 subunit gamma; PHA 1; PHA1; SCNEG; SCNN 1G; SCNN1G; SCNNG_HUMAN; Sodium channel epithelial 1 gamma subunit; Sodium channel non voltage gated 1 gamma subunit; Sodium channel nonvoltage gated 1 gamma
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
基因功能參考文獻：
1. One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified. PMID: 25900089
2. Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis. PMID: 26437894
3. Suggest that SCNN1G gene has important roles in blood pressure regulation in the Han Chinese population. PMID: 25231509
4. Data indicate that urokinase-type plasminogen activator (uPA) activates epithelial sodium channel, gamma subunit (ENaC gamma) through catalytic activity-dependent proteolytic modification. PMID: 25555911
5. High serum leptin may reduce endometrial receptivity by activating the STAT3 signal pathway and down-regulating gamma-ENaC expression in the endometrium. PMID: 25450293
6. human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with furin cleavage, and proteinuria is associated with cleavage at the putative prostasin/kallikrein site and removal of the inhibitory tract within gammaENaC PMID: 25060057
7. gamma subunit palmitoylation has a dominant role over beta subunit palmitoylation in modulating ENaC gating PMID: 24692558
8. These results suggest that the mutant gammaL511Q enhances ENaC activity by increasing channel open probability and dampens channel regulation by extracellular Na(+) and proteases. PMID: 23136006
9. Mutating two valine residues (V182 and V193) in the critical region of gammaENaC prevented proteolytic activation of ENaC by Cat-S. PMID: 22864553
10. All four ENaC subunits (alphabetagammadelta) are expressed in the normal human eye, with distinct localization of subunits possibly reflecting different functional states of the channel. PMID: 22167092
11. variants of ENaC subunits may contribute to the variation of BP response to dietary sodium intake PMID: 21562341
12. The intronic single-nucleotide polymorphism of SCNN1G (rs13331086) was significantly positively associated with higher blood pressure and urinary potassium excretion in 4 white European cohorts. PMID: 22006290
13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
14. A new nonsense mutation(Q567X) of the SCNN1G gene is likely the cause of Liddle's syndrome in family 2. PMID: 20376790
15. Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel gamma-subunit gene. PMID: 12107247
16. GammaENaC Asn530Ser mutation increases channel open probability and is consistent with abnormally high sodium reabsorption in distal nephron. First mutation in extracellular domain of ENaC subunit with increased ENaC activity and Liddle's syndrome. PMID: 12473862
17. Not only are CFTR and ENaC activated together in duct salt absorption, but ENaC activation depends on functioning CFTR. PMID: 12548396
18. Common variants of the ENaC gamma subunit confer susceptibility to human essential hypertension. PMID: 15661075
19. We conclude that overexpression of ClC-5, specifically amino acids 347-647, can alter the normal translation or trafficking of ENaC and other ion transport proteins by a mechanism that is independent of the chloride conductance of ClC-5. PMID: 15702377
20. SCNN1G is a modulator in Cystic Fibrosis. PMID: 16463024
21. 14-3-3 inhibits the interaction between the WW domains of hNedd4-2 and the PY motif of the epithelial Na(+) channel, ENaC PMID: 16716084
22. A synthetic peptide corresponding to the fragment cleaved from the gamma subunit is a reversible inhibitor of endogenous ENaCs in cells; results suggest that multiple proteases cleave ENaC gamma subunits to fully activate the channel. PMID: 17199078
23. genetic variants in ENaCgamma (epithelial sodium channel gamma) genes do not modulate disease severity in the majority of CF patients PMID: 17560176
24. Relatively common polymorphisms in the SCNN1G gene are associated with high systolic blood pressure in the general Australian white population. PMID: 17698725
25. protease binding and perhaps cleavage of the gamma subunit results in ENaC activation PMID: 17998393
26. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit PMID: 18981180
27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825
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相關疾?。?/div>
Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 3 (BESC3)
亞細胞定位：

Apical cell membrane; Multi-pass membrane protein.
蛋白家族：

Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1G subfamily
組織特異性：

Expressed in kidney (at protein level).
數據庫鏈接：

HGNC: 10602

OMIM: 177200

KEGG: hsa:6340

STRING: 9606.ENSP00000300061

UniGene: Hs.371727