Recombinant Human Activating signal cointegrator 1 complex subunit 3 (ASCC3)

中文名稱：

Recombinant Human Activating signal cointegrator 1 complex subunit 3(ASCC3)
貨號：

CSB-YP002198HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Activating signal cointegrator 1 complex subunit 3(ASCC3)
貨號：

CSB-EP002198HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Activating signal cointegrator 1 complex subunit 3(ASCC3)
貨號：

CSB-BP002198HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Activating signal cointegrator 1 complex subunit 3(ASCC3)
貨號：

CSB-MP002198HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ASCC3
Uniprot No.：

Q8N3C0
別名：

Activating signal cointegrator 1 complex subunit 3; ASC-1 complex subunit p200; ASC-1 complex subunit p200-KD subunit; ASC1p200; ascc3; ATP binding 1; B630009I04Rik; dJ121G13.4; DJ467N11.1; HELC1_HUMAN; HELIC1; Helicase; helicase; ATP binding 1; p200; RNA helicase family; RNAH; RP1-121G13.4; Trip4 complex subunit p200
種屬：

Homo sapiens (Human)
蛋白長度：

full length of Isoform 2
表達區域：

1-111
氨基酸序列

MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQIEVNCPFQKRRLDGKEEDEKMSRASDRFRGLR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
基因功能參考文獻：
1. UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. PMID: 28215706
2. ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B. PMID: 26536629
3. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses. PMID: 23781071
4. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184
亞細胞定位：

Nucleus. Nucleus speckle. Cytoplasm, cytosol.
蛋白家族：

Helicase family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 18697

OMIM: 614217

KEGG: hsa:10973

STRING: 9606.ENSP00000358159

UniGene: Hs.486031