Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3), partial

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3(ADAMTS3) ,partial
貨號：

CSB-YP001310HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3(ADAMTS3) ,partial
貨號：

CSB-EP001310HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3(ADAMTS3) ,partial
貨號：

CSB-EP001310HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3(ADAMTS3) ,partial
貨號：

CSB-BP001310HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 3(ADAMTS3) ,partial
貨號：

CSB-MP001310HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADAMTS3
Uniprot No.：

O15072
別名：

ADAMTS3; KIAA0366A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS 3; ADAM-TS3; ADAMTS-3; EC 3.4.24.-; Procollagen II N-proteinase; PC II-NP; Procollagen II amino propeptide-processing enzyme
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
基因功能參考文獻：
1. Molecular cloning and in silico analysis identify potential transcription factor binding sites in the ADAMTS3 promoter region and show that SP1 downregulated ADAMTS3 transcriptional activity in osteosarcoma cell lines. As consistent with the transcriptional activity, mRNA, and protein expression levels were also decreased by SP1. PMID: 29518549
2. Results corroborate the recent in vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 in triggering VEGFR3 signaling, a cornerstone for the differentiation and function of lymphatic endothelial cells. PMID: 28985353
3. Findings suggest that these MMP16 rs10090371, ADAMTS3 rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS). PMID: 28796414
4. The pregnancy loss rate seems to be affected by both ADAMTS-3 and ADAMTS-16. PMID: 28088271
5. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. [review] PMID: 25863161
6. ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. PMID: 22205175
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亞細胞定位：

Secreted. Secreted, extracellular space, extracellular matrix.
組織特異性：

Found in cartilage and skin.
數據庫鏈接：

HGNC: 219

OMIM: 605011

KEGG: hsa:9508

STRING: 9606.ENSP00000286657

UniGene: Hs.590919