Recombinant Human 26S proteasome non-ATPase regulatory subunit 1 (PSMD1), partial

中文名稱：

人PSMD1重組蛋白
貨號：

CSB-YP860765HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PSMD1重組蛋白
貨號：

CSB-EP860765HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PSMD1重組蛋白
貨號：

CSB-EP860765HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PSMD1重組蛋白
貨號：

CSB-BP860765HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PSMD1重組蛋白
貨號：

CSB-MP860765HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PSMD1
Uniprot No.：

Q99460
別名：

MGC133041; 26S proteasome non ATPase regulatory subunit 1; 26S proteasome non ATPase subunit 1; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit rpn2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; MGC133040; P112; Proteasome (prosome macropain) 26S subunit, non ATPase 1; Psmd1; PSMD1_HUMAN; RPN2; S1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
基因功能參考文獻：
1. RPN13 binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors and that RPN2, ubiquitin, and the deubiquitylase UCH37 bind to RPN13 with independent energetics. PMID: 28442575
2. Together, our findings suggest that the interaction of Psmd1 with Adrm1 is controlled by SUMOylation in a manner that may alter proteasome composition and function. PMID: 24910440
3. Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration compared to control subjects. PMID: 24286321
4. The 26S proteasome plays a key role in promoting apoptosis induced by high doses of UV irradiation. PMID: 22031102
5. p38 MAPK negatively regulates the proteasome activity by phosphorylating Thr-273 of Rpn2 PMID: 21044959
6. neurotoxic products of inflammation, such as PGJ2, may play a role in neurodegenerative disorders by impairing 26 S proteasome activity and inducing a chain of events that culminates in neuronal cell death PMID: 16737963
7. analysis of how subunit radial displacements open the gate into the proteolytic core in the human 26S proteasome PMID: 18534977
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蛋白家族：

Proteasome subunit S1 family
數據庫鏈接：

HGNC: 9554

OMIM: 617842

KEGG: hsa:5707

STRING: 9606.ENSP00000309474

UniGene: Hs.3887