Recombinant Helicobacter pylori Urease subunit beta (ureB)

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中文名稱：

幽門螺旋桿菌ureB重組蛋白
貨號：

CSB-YP300910HUV
說明書：

MSDS Datasheet
規格：

￥528
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP300910HUV could indicate that this peptide derived from Yeast-expressed Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureB.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP300910HUV could indicate that this peptide derived from Yeast-expressed Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureB.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

ureB
Uniprot No.：

P69996
別名：

HP_0072; hpuB; URE1_HELPY; Urea amidohydrolase subunit beta; Urease subunit beta; ureB
種屬：

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
蛋白長度：

Full Length
來源：

Yeast
分子量：

63.7kDa
表達區域：

1-569aa
氨基酸序列

MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

A full-length Helicobacter pylori Urease subunit beta (ureB) ORF (1-569aa) with an N-terminal 6xHis-tag was expressed in the yeast. The forming protein is the Recombinant Helicobacter pylori ureB protein. This ureB protein was verified by SDS-PAGE and LC-MS/MS Analyses. Its purity is greater than 90%. It has a calculated molecular mass of 63.7 kDa. This recombinant ureB protein may be used as an immunogen for specific antibody production or in the studies of gastritis and gastric cancer.

UreB is a structural subunit of urease that is critical to the metabolism and virulence of Helicobacter pylori. Urease is also necessary for Helicobacter pylori's colonization of the gastric mucosa and is a potent immunogen that triggers a vigorous immune response. Chronic Helicobacter pylori (H. pylori) infection to gastric mucosa is a common cause for gastritis and increases the risk of gastric cancer.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
基因功能參考文獻：
1. Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. PMID: 26214524
亞細胞定位：

Cytoplasm. Note=Also associates with the outer membrane upon autolysis of neighboring bacteria.
蛋白家族：

Metallo-dependent hydrolases superfamily, Urease alpha subunit family
數據庫鏈接：

KEGG: heo:C694_00350

STRING: 85962.HP0072