Recombinant Haplopelma hainanum Mu-theraphotoxin-Hhn2a
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中文名稱：Recombinant Haplopelma hainanum Mu-theraphotoxin-Hhn2a
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貨號：CSB-YP513259HUK
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說明書：
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規格：
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來源：Yeast
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其他：
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中文名稱：Recombinant Haplopelma hainanum Mu-theraphotoxin-Hhn2a
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貨號：CSB-EP513259HUK
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說明書：
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規格：
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來源：E.coli
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其他：
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中文名稱：Recombinant Haplopelma hainanum Mu-theraphotoxin-Hhn2a
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貨號：CSB-EP513259HUK-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
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中文名稱：Recombinant Haplopelma hainanum Mu-theraphotoxin-Hhn2a
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貨號：CSB-BP513259HUK
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說明書：
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規格：
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來源：Baculovirus
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：N/A
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Uniprot No.：
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別名：Hainantoxin-III 5; HnTx-III; Hainantoxin-3.5; Mu-theraphotoxin-Hhn2a; Mu-TRTX-Hhn2a; Peptide F7-18.76
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種屬：Haplopelma hainanum (Chinese bird spider) (Selenocosmia hainana)
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蛋白長度：Cytoplasmic domain
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表達區域：49-81
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氨基酸序列GC KGFGDSCTPG KNECCPNYAC SSKHKWCKVY L
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1.1/SCN1A, 270 nM on Nav1.2/SCN2A, 491 nM on Nav1.3/SCN3A and 232 nM on Nav1.7/SCN9A). This toxin suppress Nav1.7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics. Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin. This toxin increases the deactivation of the Nav1.7 current after extreme depolarizations. The toxin-Nav1.7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1.7 after a long repolarization. Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1.7. These data are consistent with this toxin interacting with Nav1.7 site 4 and trapping the domain II voltage sensor in the closed state.
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亞細胞定位：Secreted.
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蛋白家族：Huwentoxin-1 family, Hntx-3 subfamily
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組織特異性：Expressed by the venom gland.
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