Recombinant Drosophila melanogaster Tyrosine-protein phosphatase Lar (Lar), partial

中文名稱：

黑腹果蠅Lar重組蛋白
貨號：

CSB-YP322301DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅Lar重組蛋白
貨號：

CSB-EP322301DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅Lar重組蛋白
貨號：

CSB-EP322301DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅Lar重組蛋白
貨號：

CSB-BP322301DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅Lar重組蛋白
貨號：

CSB-MP322301DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lar
Uniprot No.：

P16621
別名：

Lar; CG10443; Tyrosine-protein phosphatase Lar; EC 3.1.3.48; Protein-tyrosine-phosphate phosphohydrolase; dLAR
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl. Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function.
基因功能參考文獻：
1. The authors found that the depth of the final layer of stable photoreceptor axon termination relied primarily on the cumulative amount of LAR and Ptp69D cytoplasmic activity, while specific features of their ectodomains contribute to the choice between two synaptic layers, M3 and M6, in the medulla. PMID: 29116043
2. Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue. PMID: 28292425
3. The results of this study suggested that loss of Lar alters sLNv axonal targeting in the dorsal protocerebrum during embryonic or early larval development, thereby impairing PDF signaling, synchronization of the circadian network, and rhythmic activity. PMID: 27030770
4. the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions PMID: 22378638
5. the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported. PMID: 21402080
6. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related PMID: 21430143
7. Receptor phosphatase Dlar regulates the formation and maintenance of presynaptic proteins. PMID: 11931739
8. Functions of the ectodomain and cytoplasmic protein-tyrosine-phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo were studied. PMID: 12972609
9. Results suggest that Liprin-alpha does not simply act by regulating receptor tyrosine phosphatase LAR localization but also has LAR-independent functions PMID: 16864797
10. During development of the larval mushroom body, Lar is expressed within an expanded core region including somewhat older axons. Lar is necessary for the axonal branching decisions that create the lobes. PMID: 18356078
11. LAR function in R7 is independent of its phosphatase activity, but requires structural features that allow dimerization and may promote the assembly of downstream effectors. PMID: 19889974
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein-tyrosine phosphatase family, Receptor class 2A subfamily
組織特異性：

Selectively expressed in a subset of axons and pioneer neurons in the embryo.
數據庫鏈接：

KEGG: dme:Dmel_CG10443

STRING: 7227.FBpp0303681

UniGene: Dm.24416