Recombinant Drosophila melanogaster Protein dimmed (dimm)

中文名稱：

黑腹果蠅dimm重組蛋白
貨號：

CSB-YP469628DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅dimm重組蛋白
貨號：

CSB-EP469628DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅dimm重組蛋白
貨號：

CSB-EP469628DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅dimm重組蛋白
貨號：

CSB-BP469628DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅dimm重組蛋白
貨號：

CSB-MP469628DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

dimm
Uniprot No.：

B6VQA1
別名：

dimm; CG8667Protein dimmed
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區域：

1-390
氨基酸序列

MDATQLTELM GSHDFMQLQH QLHHNNNNYN TDGHNGLSSE SAEGSSRPVR RATRRTSQLS NNTYDLEMTD SSSQSDDTSG GGGSSNGGGS TTNTGHPSGC SLGGQGPSGR GRVQQASSGA CPSTIAPNST SSNSSNANGN ASRRRKGALN AKERNMRRLE SNERERMRMH SLNDAFQSLR EVIPHVEMER RLSKIETLTL AKNYIINLTH IILSKRNEEA AALELNSGAV GGVLLSNLSS ESGGPVASGI PANSNAATIC FEDTLASGGA FDCAILAATD GSLLNAATVT TSPAMQSIQS QAIHLQTPME QQQQQASHLP HHQQAMHGHG HLGASIQSQQ QPSLVLNGTT SVGLGIGIGV GVGVGVGVCN NAPSFADIND NFDEPFREFL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes.
基因功能參考文獻：
1. DIMM prescribes the scale of secretory activity in neuroendocrine neurons, by a systematic control of both proximal and distal points in the regulated secretory pathway. PMID: 25634895
2. We also show that dInR expression in neuroendocrine cells can be altered by up or down-regulation of Dimm. PMID: 24385933
3. Loss of SSDP, a key regulatory component of CHIP/LDB transcription complexes, alters transcription of a large group of genes. PMID: 20730086
4. Nonpeptidergic neurons normally fail to accumulate ectopic neuropeptides. They will do so when they are also forced to express ectopic DIMM. PMID: 20045330
5. The roles of crc and dimmed genes on the expression of diverse hormones in D. melanogaster and reported. PMID: 16651547
6. DIMM is a master regulator of a peptidergic cell fate in Drosophila and provides a detailed transcriptional mechanism of DIMM action on a defined target gene PMID: 17967878
7. DIMMED has a special role in the development and maintenance of neurosecretory cell fate in Drosophila as a dedicated pro-secretory factor. PMID: 19135054
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亞細胞定位：

Cytoplasm.
組織特異性：

Detected in the developing nervous system in the bilateral domains in the cephalic region that later on forms part of the ring gland. Concomitantly expressed in the larval central nervous system (CNS), including the dorsal chain neurons as well as several
數據庫鏈接：

KEGG: dme:Dmel_CG8667

STRING: 7227.FBpp0305546

UniGene: Dm.23895