Recombinant Drosophila melanogaster Peptidoglycan-recognition protein SC2 (PGRP-SC2)

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文獻引用 (1) 評價 (1)

中文名稱：

黑腹果蠅PGRP-SC2重組蛋白
品名簡稱：

Recombinant Drosophila melanogaster PGRP-SC2 protein
貨號：

CSB-EP892684DLU
說明書：

MSDS Datasheet
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

PGRP-SC2
Uniprot No.：

Q9V4X2
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

25.2 kDa
表達區域：

21-184aa
氨基酸序列

VTIISKSEWGGRSATSKTSLANYLSYAVIHHTAGNYCSTKAACITQLQNIQAYHMDSLGWADIGYNFLIGGDGNVYEGRGWNVMGAHATNWNSKSIGISFLGNYNTNTLTSAQITAAKGLLSDAVSRGQIVSGYILYGHRQVGSTECPGTNIWNEIRTWSNWKA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

引用文獻

Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting Y Chen,Immunity,2022

產品評價

平均分:

5.0分 - 1 個評價

實驗應用：體外酶活性檢測

產品評價：我使用CSB-EP892684DLU的PGRP-SC2蛋白，進行了體外酶活性檢測實驗，實驗結果表明純化的PGRP-SC2蛋白可以有效的發揮其酰胺酶活性。該公司生產、純化的果蠅PGRP-SC2蛋白非常好用。

By 陳老師

靶點詳情

功能：

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
基因功能參考文獻：
1. The aging intestine of Drosophila, chronic activation of the transcription factor Foxo reduces expression of peptidoglycan recognition protein SC2 (PGRP-SC2), a negative regulator of IMD/Relish innate immune signaling, and homolog of the anti-inflammatory molecules PGLYRP1-4. PMID: 24439372
2. Report that PGRP-SC1/2-depleted flies present over-activation of the immune deficiency signaling pathway after bacterial challenge suggesting that these proteins act in the larval gut to prevent activation of this pathway following bacterial ingestion. PMID: 16518472
亞細胞定位：

Secreted.
蛋白家族：

N-acetylmuramoyl-L-alanine amidase 2 family
組織特異性：

Constitutively expressed at high level in gut, in addition to the induced expression in fat body.
數據庫鏈接：

KEGG: dme:Dmel_CG14745

STRING: 7227.FBpp0087788