Recombinant Drosophila melanogaster Kinesin-like protein costa (cos), partial

中文名稱：

Recombinant Drosophila melanogaster Kinesin-like protein costa(cos) ,partial
貨號：

CSB-YP522704DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Drosophila melanogaster Kinesin-like protein costa(cos) ,partial
貨號：

CSB-EP522704DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Drosophila melanogaster Kinesin-like protein costa(cos) ,partial
貨號：

CSB-EP522704DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Drosophila melanogaster Kinesin-like protein costa(cos) ,partial
貨號：

CSB-BP522704DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Drosophila melanogaster Kinesin-like protein costa(cos) ,partial
貨號：

CSB-MP522704DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

cos
Uniprot No.：

O16844
別名：

cos; cos2; costal-2; CG1708Kinesin-like protein costa; Kinesin-like protein costal2
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation. May negatively regulate a hh-signaling pathway which functions in the intestinal immune response to bacterial uracil by activating the Duox-dependent production of reactive oxygen species (ROS).
基因功能參考文獻：
1. Cos2 is sumoylated, which counteracts its inhibitory role on Smo accumulation in the wing. PMID: 28195188
2. Data show Ci interaction with Su(fu) or Cos2 correlates with Su(fu)- or Cos2-mediated suppression of Ci activity PMID: 26271100
3. The CORD region of Ci has a second function distinct from Cos2 binding that inhibits Ci processing. Cos2 binding to CORD relieves this inhibition. PMID: 20850429
4. analysis of phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling PMID: 20435030
5. Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner PMID: 14645371
6. Cos2 recruits multiple kinases to efficiently phosphorylate Cubitus interruptus. PMID: 15691767
7. Differential Hh target gene regulation can be accomplished by differential sensitivity of Cos2 and Su(Fu) to Hh. PMID: 15750186
8. Cos2 motility plays an important role in its function, regulating the amounts and activity of Ci that ultimately interpret the level of Hh to which cells are exposed. PMID: 18691888
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF27 subfamily
數據庫鏈接：

KEGG: dme:Dmel_CG1708

STRING: 7227.FBpp0088087

UniGene: Dm.5775