Recombinant Drosophila melanogaster Disks large 1 tumor suppressor protein (dlg1), partial

中文名稱：

黑腹果蠅dlg1重組蛋白
貨號：

CSB-YP329033DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅dlg1重組蛋白
貨號：

CSB-EP329033DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅dlg1重組蛋白
貨號：

CSB-EP329033DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅dlg1重組蛋白
貨號：

CSB-BP329033DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅dlg1重組蛋白
貨號：

CSB-MP329033DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

dlg1
Uniprot No.：

P31007
別名：

dlg1; l(1)dlg1; CG1725Disks large 1 tumor suppressor protein
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
基因功能參考文獻：
1. The authors find that the tumor suppressor Discs large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindle orientation factor GukHolder (GukH). PMID: 29185419
2. The structure of dlg1 reveals that the core of the dimer is formed by a distinctive six-helix assembly, involving all three conserved helices from each subunit (monomer). The homodimer interface is extended by the C-terminal tail of the L27 domain of Dlg1, which forms a two-stranded antiparallel beta-sheet. The structure reconciles and provides a structural context for a large body of available mutational data. PMID: 29261291
3. Strikingly the absence of any of DLG proteins at the presynaptic terminal disrupts the clustering and localization of the calcium channel DmCa1A subunit (Cacophony), decreases the action potential-evoked release probability and alters short-term plasticity. PMID: 27573697
4. Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD). The data place Bnd at the top of the hierarchy of the factors involved in ACD, suggesting that its main function is mediating localization and function of Dlg tumor suppressor. PMID: 25088559
5. The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis. PMID: 25509107
6. Loss of scrib, dlg and lgl had no effect on gonad formation, but Dlg and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads. PMID: 23585349
7. Gliotactin and Discs large are co-regulated to maintain epithelial integrity. PMID: 23321643
8. Hts regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells. PMID: 21791202
9. Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg. PMID: 20810883
10. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization PMID: 20427642
11. Study provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. PMID: 19948068
12. integrins act through CaMKII activation to control the localization of dlg in the development of NMJ synaptic morphology PMID: 12091308
13. conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts PMID: 12545176
14. Isoforms of Dlg are fundamental for neuronal development in Drosophila PMID: 12657668
15. role in development of cell boundaries for cell nuclei in Drosophila embryos in conjunction with Strabismus protein PMID: 14562058
16. recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms; DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses PMID: 15039455
17. DLG controls glutamate receptor subunit (GluR) composition by selectively stabilizing GluRIIB subunit-containing receptors at the synapse. PMID: 15638945
18. Novel spatiotemporal patterns of epithelial tumor invasion in Drosophila disc large egg chambers were studied. PMID: 15712204
19. multiple interdomain interactions in the scaffold Discs Large (Dlg) regulate binding to the synaptic protein GukHolder (GukH) PMID: 16982606
20. DLG regulates the formation of sodium dodecyl sulfate-resistant target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes containing guanylate kinase-like-interacting syntaxin GTX. PMID: 17267557
21. Study identified a previously unrecognized evolutionarily conserved Pins domain (Pins(LINKER)) that requires Aurora-A phosphorylation to recruit Dlg and promote partial spindle orientation. PMID: 19766567
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亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, septate junction.
蛋白家族：

MAGUK family
組織特異性：

During the cellular blastoderm stage, isoform B, isoform F, isoform H, isoform I and isoform L expression is localized to the cell borders. From stage 11 onwards, expression is found predominantly in the developing nervous system: axon bundles in the vent
數據庫鏈接：

KEGG: dme:Dmel_CG1725

STRING: 7227.FBpp0290503

UniGene: Dm.4352