Recombinant Drosophila melanogaster Calcium-activated potassium channel slowpoke (slo), partial

中文名稱：

黑腹果蠅slo重組蛋白
貨號(hào)：

CSB-YP311814DLU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅slo重組蛋白
貨號(hào)：

CSB-EP311814DLU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅slo重組蛋白
貨號(hào)：

CSB-EP311814DLU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅slo重組蛋白
貨號(hào)：

CSB-BP311814DLU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅slo重組蛋白
貨號(hào)：

CSB-MP311814DLU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

slo
Uniprot No.：

Q03720
別名：

slo; CG10693; Calcium-activated potassium channel slowpoke; dSlo; BK channel; Maxi K channel; MaxiK
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob1 and 14-3-3-zeta decreases its activity.
基因功能參考文獻(xiàn)：
1. Removal of element 6b from the endogenous slo gene affected the production of functional ethanol tolerance in an ethanol-vapor recovery from sedation assay. PMID: 26992698
2. slowpoke channels are required specifically in motoneurones for maximum firing rates during locomotion. PMID: 26332699
3. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels PMID: 26823461
4. Slo mutant larvae exhibit alterations in synapse morphology, active zone size and neurotransmission that are similar to dysc mutants. PMID: 25359729
5. Results show using the Drosophila model organism, we demonstrate a central role for the BK-type Ca(2+) -activated K(+) channel gene slo in the production of alcohol withdrawal seizures PMID: 22734584
6. Here we examined the action of docosahexaenoic acid on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity. PMID: 24127525
7. Our work identifies a Drosophila homolog of a deaf-blindness gene as a new component of the circadian output pathway,termed DYSC(dyschronic) whish expressed in major neuronal tracts and regulates expression of SLOWPOKE PMID: 22532808
8. Our work identifies a Drosophila homolog of a deaf-blindness gene as a new component of the circadian output pathway,termed DYSC(dyschronic) whish expressed in major neuronal tracts and regulates expression of SLOWPOKE (SLO) PMID: 22532808
9. Involved with Slob protein in the circadian regulation of rhythmic locomotor behavior PMID: 12417656
10. the slowpoke channel must be involved in triggering or producing a homeostatic mechanism that opposes the sedative effects of ethanol. PMID: 16269907
11. The Drosophila slowpoke gene includes 14 alternative exons distributed among five sites of alternative splicing. Slowpoke transcripts undergo tissue- and developmental-specific splicing in Drosophila and some exons are diagnostic for specific tissues. PMID: 16716202
12. These results implicate distinct calcium-dependent and -independent mechanisms in the modulation of dSlo by Slob PMID: 17074977
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亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, Slo sub-subfamily
組織特異性：

Expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. During pupariation and embryogenesis, it is expressed in muscles many hours prior to
數(shù)據(jù)庫(kù)鏈接：

KEGG: dme:Dmel_CG10693

UniGene: Dm.19520