Recombinant Dog Claudin-2 (CLDN2), partial

中文名稱：

Recombinant Dog Claudin-2(CLDN2),partial
貨號：

CSB-YP836096DO1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Dog Claudin-2(CLDN2),partial
貨號：

CSB-EP836096DO1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Dog Claudin-2(CLDN2),partial
貨號：

CSB-EP836096DO1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Dog Claudin-2(CLDN2),partial
貨號：

CSB-BP836096DO1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Dog Claudin-2(CLDN2),partial
貨號：

CSB-MP836096DO1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CLDN2
Uniprot No.：

Q95KM6
別名：

CLDN2; Claudin-2
種屬：

Canis familiaris (Dog) (Canis lupus familiaris)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
基因功能參考文獻：
1. hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells. PMID: 27733684
2. Claudin-2 independently determines the 'leaky' property of Tight Junctions in MDCK II cells. PMID: 25781928
3. PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier. PMID: 25694446
4. IQGAP1 modulates TJ formation by a twofold mechanism: (1) controlling the expression and recruitment of claudin 2 and recruitment of claudin 4 to the TJ, and (2) transient inhibition of the CDC42-JNK pathway. PMID: 25588839
5. These results suggest that hyperosmolarity decreases the expression level of claudin-2 via a decrease in PKCbeta-dependent GATA-2 transcriptional activity in renal tubular epithelial cells PMID: 25825272
6. These results implicate Rab14 in specialized trafficking of claudin-2 from the recycling endosome. PMID: 24694596
7. these results indicate that EGF controls the levels of CLDN-2 and -4 proteins and mRNAs through Src and STAT3 activity. PMID: 24909426
8. YM201636 treatment blocks the continuous recycling of claudin-1/claudin-2 and delays epithelial barrier formation PMID: 22396724
9. Epidermal growth factor accelerates clathrin-dependent endocytosis and lysosomal degradation of CLDN2 protein. PMID: 21660968
10. These results suggest that the decrease in claudin-2 expression enhances cell migration mediated by the increase in the expression and activity of MMP-9. PMID: 20717932
11. the ERK 1/2 signaling pathway negatively controls claudin-2 expression in mammalian renal epithelial cells and provide evidence for regulation of tight junction paracellular transport by alterations in claudin composition within tight junction complexes. PMID: 15569684
12. These results provide novel insights about the mechanisms of cingulin function and the signaling pathways controlling claudin-2 expression in Madin-Darby canine kidney (MDCK) cells. PMID: 16723500
13. Claudin-2 expression markedly increased in the proximal crypt and luminal colonic epithelium in affected dogs, suggesting a role in the pathogenesis of canine LPC. PMID: 17595339
14. The discovery of claudin 2 transcript and protein in the skin could be of importance in epidermal differentiation, barrier function and pathological conditions. PMID: 18509255
15. LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation. PMID: 19295125
16. Report downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis. PMID: 19587148
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亞細胞定位：

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Claudin family
數據庫鏈接：

KEGG: cfa:403649

STRING: 9615.ENSCAFP00000036941

UniGene: Cfa.3514