Recombinant Danio rerio Poly (ADP-ribose) glycohydrolase ARH3 (adprhl2)

中文名稱：

Recombinant Danio rerio Poly(ADP-ribose) glycohydrolase ARH3(adprhl2)
貨號：

CSB-YP734525DIL
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Danio rerio Poly(ADP-ribose) glycohydrolase ARH3(adprhl2)
貨號：

CSB-EP734525DIL
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Danio rerio Poly(ADP-ribose) glycohydrolase ARH3(adprhl2)
貨號：

CSB-EP734525DIL-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Danio rerio Poly(ADP-ribose) glycohydrolase ARH3(adprhl2)
貨號：

CSB-BP734525DIL
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Danio rerio Poly(ADP-ribose) glycohydrolase ARH3(adprhl2)
貨號：

CSB-MP734525DIL
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

adprhl2
Uniprot No.：

Q66HT8
別名：

adprhl2; arh3; zgc:92867; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; EC 3.5.1.-; Poly(ADP-ribose) glycohydrolase ARH3; EC 3.2.1.143; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; EC 3.2.2.-
種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
蛋白長度：

full length protein
表達區域：

1-370
氨基酸序列

MSAAARVVAP VMMLSRFRGA LVGSVLGDCI GGEFEGAVDV PLDRVLQHLS ALEDDTRGDG ILQYSDDTAM MRCVADSLLT RMTFDERDMA QRFAKEYSHS PGRGYGSGVV QVLRKLASPH LKDVFQPAQA QFGGRGSFGN GGAMRAVPFA LAFRSRADVR KYSRFGAMLT HSCSLGYNGA ALQALAVHLS LQGALALPKD FIDKLISEME ELEKDETAKH DAKALNLSEF PYCSRLHRVK ELMDKTSVSI EEVISELGNG IAALQSVPTA IFCVLYCLEP QDGLPERFGG LERTIAYSLA LGGDTDTIAC MAGAIAGAHY GIDSIPLSWQ VSCEGVDEAD DLARRLYDLY CLPQHNEDRG NNQPHTTNTD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
亞細胞定位：

Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix.
蛋白家族：

ADP-ribosylglycohydrolase family
數據庫鏈接：

KEGG: dre:796446

STRING: 7955.ENSDARP00000027022

UniGene: Dr.80280