Recombinant Danio rerio Growth/differentiation factor 6-A (gdf6a)
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中文名稱：斑馬魚gdf6a重組蛋白
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貨號：CSB-EP309201DIL-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：gdf6a
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Uniprot No.：
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別名：gdf6a; radar; rdrGrowth/differentiation factor 6-A; GDF-6-A; Growth differentiation factor 6A; Protein radar
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種屬：Danio rerio (Zebrafish) (Brachydanio rerio)
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蛋白長度：Full Length of Mature Protein
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表達區域：285-404
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氨基酸序列TALNNR HGKRHGKKSK SRCSKKALHV NFKELGWDDW IIAPLDYEAY HCEGVCDFPL RSHLEPTNHA IIQTLMNSMD PNSTPPSCCV PTKLSPISIL YIDSGNNVVY KQYEDMVVEQ CGCR
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.
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基因功能參考文獻：
- The role of Gdf6a signaling in superior ocular sulcus morphogenesis. PMID: 29522511
- This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates. PMID: 24681822
- gdf6a is a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination. PMID: 22921921
- Radar is regulated in the pharyngeal arches by a distant conserved element and has similar functions in skeletal development in fish and mammals. PMID: 20201106
- Maternal induction of bone morphogenetic proteins by Radar is essential for zebrafish development as its removal results in larval-lethal dorsalized phenotypes. PMID: 12601179
- Radar protein expression provides insights into dorsoventral patterning. PMID: 12682283
- The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development. PMID: 17236135
- These data establish the important role of growth differentiation factor 6 in ocular and vertebral development. PMID: 19129173
- Radar is near the top of a signaling cascade that establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map PMID: 19164594
- Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation. PMID: 19545559
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亞細胞定位：Secreted.
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蛋白家族：TGF-beta family
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組織特異性：First expressed in late gastrula stage embryos (9.5 hours post fertilization (hpf)) in anterior neuroectoderm corresponding to the future dorsal part of the brain. Shortly after tailbud formation (11 hpf), expression expands to the entire neural region an
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