Recombinant Chicken Protein cereblon (CRBN)

中文名稱：

Recombinant Chicken Protein cereblon(CRBN)
貨號：

CSB-YP005944CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Chicken Protein cereblon(CRBN)
貨號：

CSB-EP005944CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Chicken Protein cereblon(CRBN)
貨號：

CSB-EP005944CH-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Chicken Protein cereblon(CRBN)
貨號：

CSB-BP005944CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Chicken Protein cereblon(CRBN)
貨號：

CSB-MP005944CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CRBN
Uniprot No.：

P0CF65
別名：

CRBNProtein cereblon
種屬：

Gallus gallus (Chicken)
蛋白長度：

Full length protein
表達區(qū)域：

1-445
氨基酸序列

MAAEEGGDGR RNMGNPPPPA PAESEEEDDN EMEVEDQDGK EAEKPNMINF DTSLPTSHMY LGSDMEEFHG RTLHDDDSCQ VIPVLPHVMV MLIPGQTLPL QLFHPQEVSM VRNLIQKDRT FAVLAYSNVR EREAHFGTTA EIYAYREEQE YGIETVKVKA IGRQRFKVLE IRTQSDGIQQ AKVQILPERV LPSTMSAVQL QSLSRRHIFP SSKPKVWQDR AFRQWWQKYQ KRKFHCASLT SWPPWLYSLY DAETLMERVK RQLHEWDENL KDESLPTNPI DFSYRVAACL PIDDALRIQL LKIGSAIQRL RCELDIMNKC TSLCCKQCQD TEITTKNEIF SLSLCGPMAA YVNPHGYIHE TLTVYKACNL NLSGRPSTEH SWFPGYAWTI AQCRICGNHM GWKFTATKKD MSPQKFWGLT RSALLPRIPE AEDELGHDRS PLLCL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

CRBN family
數(shù)據(jù)庫鏈接：

STRING: 9031.ENSGALP00000013451

UniGene: Gga.17910