Recombinant Chicken Glucagon (GCG)

中文名稱：

雞GCG重組蛋白
貨號：

CSB-YP009315CH
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

雞GCG重組蛋白
貨號：

CSB-EP009315CH
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

雞GCG重組蛋白
貨號：

CSB-EP009315CH-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞GCG重組蛋白
貨號：

CSB-BP009315CH
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

雞GCG重組蛋白
貨號：

CSB-MP009315CH
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GCG
Uniprot No.：

P68259
別名：

GCGGlucagon [Cleaved into: Glicentin-related polypeptide; GRPP); Glucagon; Glucagon-like peptide 1; GLP-1); Glucagon-like peptide 1(7-37; GLP-1(7-37)); Glucagon-like peptide 1(7-36; GLP-1(7-36)); Glucagon-like peptide 2; GLP-2)]
種屬：

Gallus gallus (Chicken)
蛋白長度：

Cytoplasmic domain
表達區域：

23-52
氨基酸序列

NPLQDTEE KSRSFKASQS EPLDESRQLN EV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.; Potent stimulator of glucose-dependent insulin release. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation.; Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.
基因功能參考文獻：
1. These findings reveal that the cells producing both GLP-1 and NT are mainly localized in the crypts of the chicken ileum. PMID: 28108848
2. It plays a role in the regulation of food intake in chickens. (review) PMID: 27150835
3. Data show there was an interaction of line and nutrition on preproglucagon (PPG) and glucose transporter GLUT2 mRNA expression. PMID: 26260898
4. These data show that the quantity of food intake is one of signals that have an influence on the secretion of GLP-1 from L cells in the chicken small intestine. PMID: 23651280
5. Hypothalamic GCGL is most likely to be a novel TSH-releasing factor functioning in chickens. PMID: 25076122
6. findings suggest that GCGL functions as an anorexigenic peptide in the central nervous system of chicks. PMID: 24361510
7. results suggest that ventromedial hypothalamic nucleus and some brain regions are involved in the anorexic effect of GLP-1 in chicks PMID: 14720603
8. Plasma glucagon levels remain low until the 17th embryonic day, and then significantly increased approximately 3-fold at hatch of chickens. PMID: 17369538
9. these results offer new insights into structure and function of the chicken proglucagon gene PMID: 18299131
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亞細胞定位：

Secreted.
蛋白家族：

Glucagon family
數據庫鏈接：

KEGG: gga:396196

STRING: 9031.ENSGALP00000018068

UniGene: Gga.704