Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE (BRE)

中文名稱：

Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE(BRE)
貨號：

CSB-YP002808BVY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE(BRE)
貨號：

CSB-EP002808BVY
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE(BRE)
貨號：

CSB-EP002808BVY-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE(BRE)
貨號：

CSB-BP002808BVY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Branchiostoma floridae BRCA1-A complex subunit BRE(BRE)
貨號：

CSB-MP002808BVY
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

BABAM2
Uniprot No.：

B6NXD5
別名：

BABAM2; BRE; BRAFLDRAFT_269508BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein
種屬：

Branchiostoma floridae (Florida lancelet) (Amphioxus)
蛋白長度：

full length protein
表達區(qū)域：

1-383
氨基酸序列

MSSGQSVLKQ LHPLIRPYAE TVLRKGNVGV CMGNLRISDV KSGRPTLTQT KEPCGDRFKI YIPFAGDSLK WEVIFDSCQP SNPPDFIFLG ENGNFDPDIE KLENLTHWDP KNPESLVLAI EDLMREYRCY QKQLIEGYSR LQFEYSSLQG MEACDDVEVH MGNRLPGTLD SPVNFLIRLP IDLSPIPQYL VKDDPGEDLA VLLAKFHNSE GSRVTPQLFL SPKVEHALGD NTALRIPRFP TGGCLMDYVP QVQDFLQKQI DHIVEGYQRR REYVAAFISR FGGSVLEYDA ESFTKLSLVL EWNEFFFVLH IELPSRFPQD MPVFTFQSCY HLSKTNGEPY VSVQKSYPYS PRWTGEEMAH RAKLFILDFI PQFKKVSVSS NKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

BABAM2 family
數(shù)據(jù)庫鏈接：

STRING: 7739.JGI269508