Recombinant Bovine Interferon regulatory factor 3 (IRF3)

中文名稱：

牛IRF3重組蛋白
貨號：

CSB-YP011818BO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

牛IRF3重組蛋白
貨號：

CSB-EP011818BO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

牛IRF3重組蛋白
貨號：

CSB-EP011818BO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛IRF3重組蛋白
貨號：

CSB-BP011818BO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

牛IRF3重組蛋白
貨號：

CSB-MP011818BO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

IRF3
Uniprot No.：

Q4JF28
別名：

IRF3; Interferon regulatory factor 3; IRF-3
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達區域：

1-417
氨基酸序列

MGTQKPRILP WLISQLDRGE LEGVAWLGES RTRFRIPWKH GLRQDAQQED FGIFQAWAVA SGAYTPGKDK PDLPTWKRNF RSALNRKEVL RLAEDHSKDS QDPHKIYEFV NSGVRDIPEP DTSQDNGRHN TSDTQEDTLE KLLSDMDLSP GGPSNLTMAS EKPPQFLQSP DSDIPALCPN SGLSENPLKQ LLANEEDWEF EVTAFYRGCQ VFQQTVFCPG GLRLVGSEAG DRMLPGQPIR LPDPATSLTD KSVTDYVQRV LSCLGGGLAL WRAGQWLCAQ RLGHCHVYWA IGEELLPSCG HKPDGEVPKD REGGVFNLGP FITDLITFIE GSRRSPLYTL WFCVGQSWPQ DQPWIKRLVM VKVVPMCLRV LVDIARQGGA SSLENTVDLH ISNSDPLSLT PDQYMACLQD LAEDMDF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
基因功能參考文獻：
1. These results link the stimulation of the innate immune response observed in 3 NCR-transfected cells to the intracellular type I IFN signaling pathway and suggest the potential use of these molecules for antiviral strategies in cattle. PMID: 29981712
2. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation. PMID: 21689696
3. cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon synthesis. PMID: 17531282
亞細胞定位：

Cytoplasm. Nucleus. Mitochondrion.
蛋白家族：

IRF family
數據庫鏈接：

KEGG: bta:516979

STRING: 9913.ENSBTAP00000031815

UniGene: Bt.45332