Recombinant Bovine Corticosteroid 11-beta-dehydrogenase isozyme 2 (HSD11B2)

中文名稱：

牛HSD11B2重組蛋白
貨號：

CSB-YP010765BO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

牛HSD11B2重組蛋白
貨號：

CSB-EP010765BO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

牛HSD11B2重組蛋白
貨號：

CSB-EP010765BO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛HSD11B2重組蛋白
貨號：

CSB-BP010765BO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

牛HSD11B2重組蛋白
貨號：

CSB-MP010765BO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HSD11B2
Uniprot No.：

O77667
別名：

HSD11B2; Corticosteroid 11-beta-dehydrogenase isozyme 2; EC 1.1.1.-; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
種屬：

Bos taurus (Bovine)
蛋白長度：

Full length protein
表達區域：

1-404
氨基酸序列

MESWPWPSGG AWLLVPARAL LQLLRADLRL GRPLLAALAL LAALDWLCQR LLPPLAALAV LAATGWIVLS RLARPQRLPV ATRAVLITGC DSGFGNATAK KLDTMGFTVL ATVLDLNSPG ALELRACCSS RLKLLQMDLT KPGDISRVLE FTKVHTPSTG LWGLVNNAGQ NIFVADAELC PVATFRTCME VNFFGALEMT KGLLPLLRRS SGRIVTVSSP AGDMPFPCLA AYGTSKAALA LLMGNFSCEL LPWGVKVSII QPACFKTESV KDVHQWEERK QQLLATLPQE LLQAYGEDYI EHLNGQFLHS LSQALPDLSP VVDAITDALL AAQPLRRYYP GHGLGLIYFI HYYLPEGLRQ RFLQSFFISP YVPRALQAGQ PGLTSARDIA QDQGPRPDPS PTAQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone.
基因功能參考文獻：
1. investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers PMID: 20710123
亞細胞定位：

Microsome. Endoplasmic reticulum.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Highly expressed in kidney, adrenal and colon; detected at lower levels on lung and liver.
數據庫鏈接：

KEGG: bta:282434

STRING: 9913.ENSBTAP00000007470

UniGene: Bt.49451