Recombinant Bovine Alpha-crystallin A chain (CRYAA)

中文名稱：

Recombinant Bovine Alpha-crystallin A chain(CRYAA)
貨號：

CSB-YP006007BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Bovine Alpha-crystallin A chain(CRYAA)
貨號：

CSB-EP006007BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Bovine Alpha-crystallin A chain(CRYAA)
貨號：

CSB-EP006007BO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Bovine Alpha-crystallin A chain(CRYAA)
貨號：

CSB-BP006007BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Bovine Alpha-crystallin A chain(CRYAA)
貨號：

CSB-MP006007BO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CRYAA
Uniprot No.：

P02470
別名：

CRYAA; CRYA1Alpha-crystallin A chain [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168)]
種屬：

Bos taurus (Bovine)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-173
氨基酸序列

MDIAIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ EDFVEIHGKH NERQDDHGYI SREFHRRYRL PSNVDQSALS CSLSADGMLT FSGPKIPSGV DAGHSERAIP VSREEKPSSA PSS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
基因功能參考文獻(xiàn)：
1. Data show that both green and red light wavelengths induce structural changes in betaL-crystalline. PMID: 26656181
2. For moderate O-GlcNAcylation on bovine crystalline alpha, the preferred amino acids were Pro > Ala > Gly at position -2, Ala > Thr >Val > Lys > Pro at position -1, and Ala > Gly > Arg > Glu at position +2. PMID: 24760753
3. We show that proteases with the potential to generate alphaA-66-80 peptide are present in bovine and human lenses. PMID: 23410823
4. These results show that between pH 7 and 10 the protein undergoes a reversible thermal transition. PMID: 21445944
5. alpha-crystallin is characterized by homogeneous distribution of scattering density in the domains inaccessible for water penetration PMID: 21314599
6. Results show that structural perturbations by high hydrostatic pressures enhance the chaperone-like activity of alpha-crystallin. PMID: 12485117
7. new light on structural properties of alpha-crystallin and its superhydration properties and have important implications for understanding the mechanism of the chaperone-like action of this protein in the lens and non-ocular tissues PMID: 14616086
8. Alpha-crystallin, in the presence of the sorbitol dehydrogenase (SDH) pyridine cofactor NAD(H), can exert a remarkable chaperone action by favoring the recovery of the enzyme activity from chemically denaturated SDH up to 77%. PMID: 15747064
9. Conserved triad in alphaA-crystallin contributes to stability of higher order oligomers but is not essential for formation of tetramers. PMID: 17960114
10. The spatial distributions of alpha-crystallin and its modified forms in bovine and rabbit lenses, were analysed. PMID: 18334935
11. The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens. PMID: 18509547
12. Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins. PMID: 19085379
13. The structure and properties of alpha-crystallin have changed relatively little during the evolutionary period from the emergence of sharks and mammals. PMID: 19956560
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Small heat shock protein (HSP20) family
數(shù)據(jù)庫鏈接：

KEGG: bta:281718

STRING: 9913.ENSBTAP00000004073

UniGene: Bt.397