YY1 Recombinant Monoclonal Antibody
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中文名稱：YY1重組抗體
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貨號：CSB-RA026297A0HU
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規(guī)格：￥1320
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA026297A0HU YY1重組單克隆抗體是經(jīng)ELISA嚴格驗證的高性能科研試劑，靶向轉錄因子YY1（Yin Yang 1）。該抗體通過重組表達技術制備，具有優(yōu)異的批次穩(wěn)定性和抗原結合一致性。YY1作為多功能轉錄調(diào)控因子，在表觀遺傳修飾、DNA損傷修復及細胞周期調(diào)控中發(fā)揮關鍵作用，其異常表達與多種疾病相關生物學過程密切相關。實驗數(shù)據(jù)顯示，該抗體在ELISA平臺中展現(xiàn)出高親和力與低交叉反應性，能夠精準識別天然構象與重組表達的YY1蛋白，適用于基因表達調(diào)控網(wǎng)絡研究、蛋白質(zhì)相互作用分析及靶向YY1的信號通路機制探索等科研場景。本產(chǎn)品可為表觀遺傳學、腫瘤生物學及干細胞分化等領域的體外實驗提供可靠的檢測工具，尤其適用于需要對YY1進行定量或半定量分析的實驗體系。
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Uniprot No.：
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基因名：YY1
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別名：CF1 antibody; Delta antibody; Delta transcription factor antibody; INO80 complex subunit S antibody; INO80S antibody; NF E1 antibody; NF-E1 antibody; NFE1 antibody; OTTHUMP00000197459 antibody; Transcriptional repressor protein YY1 antibody; TYY1_HUMAN antibody; UCR motif DNA binding protein antibody; UCRBP antibody; Yin and yang 1 antibody; Yin and Yang 1 protein antibody; Yin Yang 1 antibody; Ying Yang 1 antibody; YY 1 antibody; YY 1 transcription factor antibody; YY-1 antibody; YY1 antibody; YY1 transcription factor antibody
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反應種屬：Human
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免疫原：A synthesized peptide derived from human YY1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：3A11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
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基因功能參考文獻：
- Data show that MiR-147b targets the 3' untranslated region (3'UTR) of Yin Yang 1 (YY1). PMID: 30060075
- Results show that YY1 is phosphorylated by c-Abl kinase at tyrosine residue 254 and that this phosphorylation likely modulates its transcriptional activity. PMID: 29807053
- YY1-CDKN3-MDM2/P53-P21 axis is involved in pancreatic tumorigenesis PMID: 29168185
- The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858
- expression of miR-192-5p was negatively correlated with that of YY1 in bladder cancer tissues PMID: 29536411
- YY1 promoted glioma cell proliferation and miR218 could inhibit glioma cell proliferation by targeting YY1. PMID: 29138857
- miR-30a acts in a feedback loop to modulate the pro-autophagic activities of YY1. PMID: 29052509
- Data suggest a role for YY1 transcription factor (YY1) in transcriptional activity on inactive X (Xi) in general through sequence-specific binding, and its involvement at superloop anchors. PMID: 27857184
- Results suggest that up-regulation of YY1 is closely associated with the progression of cervical squamous cell carcinoma, and YY1 may play an important role in the pathogenesis of cervical cancer by modulating the expression of E-cadherin and HPV16 E6. PMID: 29470526
- Results show that histone deacetylase 1 (HDAC1) expression was positively correlated with YY1 transcription factor (YY1) in hepatocellular carcinoma (HCC) cell lines and primary tumor tissues. PMID: 28489564
- Authors found that YY1 and STAT1 were upregulated in ox-LDL-stimulating macrophages followed by translocation in the nucleus and binding to the transcriptional promoter region of miR-29a, thus leading to the increase of miR-29a expression. PMID: 28593745
- results support a model in which YY1 acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions. PMID: 28536180
- High expression of nuclear YY1 was significantly associated with higher AJCC stage and small vessel invasion. PMID: 28412749
- This is the first report on the status of YY1 T372R in insulinoma cases of Indian origin. PMID: 28472826
- YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression. PMID: 28485541
- These data suggested that YY1 may be important for apoptosis induction via the regulation of Fas during sepsis. Therefore, Fas may be a potential therapeutic target to prevent MOD through regulation of YY1 expression. Furthermore, YY1 and Fas expression in PBMCs may be used to as prognostic markers. PMID: 28447715
- Study shows that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. PMID: 29224777
- YY1 was over-expressed in RA which can bind to the promotor of IL-6 to introduce IL-6 expression, contributing to the inflammation of RA via stimulation of Th17 differentiation. PMID: 27829535
- YY1 promotes apoptosis via upregulating Bax transcription and subsequent activation of Bax by translocation from the cytosol to the mitochondrial membrane. PMID: 27074573
- High YY1 expression is associated with Lung Cancer Progression. PMID: 28972861
- Low YY1 expression is associated with pancreatic ductal adenocarcinoma. PMID: 28867247
- PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12. PMID: 23805300
- YY1 promotes mTORC2-mediated AKT activation PMID: 26762111
- these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators. PMID: 28575647
- Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described. PMID: 27428271
- ZFs of YY1 are able to interact with multiple RNA sequences, and that their specificity is not limited to putative endogenous RNA target Xist. The mode of interaction appears to be distinct from both the DNA binding of YY1 and the RNA binding of other classical ZF proteins. PMID: 27369384
- the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex. PMID: 27535137
- miR-215 is downregulated in colon cancer and it suppresses colon cancer cell proliferation, migration and invasion by directly targeting YY1 PMID: 27663660
- High YY1 expression is Associated with Endometrial Cancer. PMID: 27259051
- Our results suggested that YY1 depletion repressed prostate cancer cell viability and proliferation and induced apoptosis at least in a miR-146a-assisted manner. PMID: 28101571
- Knockdown of miR-381 target gene, YY1, mimicked the phenotype induced by miR-381 overexpression. PMID: 26768613
- SET7/SET9-mediated YY1 methylation was shown to be involved in YY1-regulated gene transcription and cell proliferation. PMID: 26902152
- The results of our study indicate that YY1 belongs to the family of intrinsically disordered proteins, which exist natively in a partially unfolded conformation. PMID: 25963536
- Study shows that YY1 regulates inflammatory responses in vascular endothelium through its binding to ANRIL. PMID: 26618242
- YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
- Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies: the mutation does not affect the secondary structure of either zinc fingers or the N-terminal fragment of the protein. PMID: 26910132
- YY1 overexpression contributes to EZH2 recruitment for H3K27me3-mediated silencing of tumour-suppressive microRNAs, thereby activating NF-kappaB signalling in hepatocarcinogenesis. PMID: 26800240
- IL-18 induced YY1 expression, which repressed FXR and MRP2 expression in HepG2 cells. PMID: 26292095
- YY1 is overexpressed in differentiated thyroid cancer, and more frequently overexpressed in the papillary carcinoma subtype. PMID: 25698133
- Results identify a novel YY1 ~ miR-9 ~ RYBP axis involved in melanoma tumorigenesis and reinforce the idea that regulatory circuitries involving miRNAs and TFs are prevalent mechanisms. PMID: 26104682
- Rescue experiments indicated that the suppressive effect of miR-34a on invasion and migration was mediated by activating YY1 expression. PMID: 25954903
- Results demonstrate that YY1 is a critical effecter in IL-13-induced fibroblast differentiation: increasing YY1 enhances it whereas decreasing YY1 reduces it. PMID: 25775215
- These findings imply that the T allele significantly suppresses PSCA expression in vivo by recruiting YY1 to its promoter, which eventually predisposes gastric epithelial cells to GC development PMID: 25727947
- Data show that YY1 transcription factor (YY1) is tyrosine-phosphorylated by Src family kinases, leading to down-regulation of its activity. PMID: 26198631
- YY1 is a transcription repressor of FEN1 regulating FEN1 levels in response to DNA damaging agents. PMID: 25885449
- These data demonstrate the crucial requirement for YY1 in lung morphogenesis. PMID: 26329601
- Transcription factor YY1 is critically involved in the chromatin remodeling and chromosomal interactions at the Th2 cytokine locus. PMID: 25764217
- The somatic Thr372Arg YY1 mutation is a relevant finding in female patients with sporadic insulinomas. PMID: 25763608
- YY1 is necessary to maintain the steady-state level of VEGFA expression while its silencing increases VEGFA mRNA half-life at 4 h and impairs the maturation of miRNA 200b/c. PMID: 25644713
- YY1 regulates, in a sex-specific manner, Mena expression in heart failure PMID: 25935483
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相關疾病：Gabriele-de Vries syndrome (GADEVS)
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亞細胞定位：Nucleus matrix. Note=Associated with the nuclear matrix.
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蛋白家族：YY transcription factor family
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