TSPAN8 Recombinant Monoclonal Antibody
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中文名稱：TSPAN8 Recombinant Monoclonal Antibody
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貨號：CSB-RA025166MA1HU
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規格：￥1320
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圖片：
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The Binding Activity of TSPAN8 with Anti-TSPAN8 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSPAN8 (CSB-MP025166HU) at 5 μg/mL can bind Anti-TSPAN8 recombinant antibody. The EC50 is 2.261-2.623 ng/mL.The VLPs (CSB-MP3838) is negative control. -
Untransfected MC38 cells (green line) and transfected Human TSPAN8 MC38 stable cells (red line) were stained with anti-TSPAN8 antibody (CSB-RA025166MA1HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry. -
The purity of TSPAN8 was greater than 95% as determined by SEC-HPLC
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其他：
產品詳情
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產品描述：TSPAN8重組單克隆抗體（CUSABIO貨號：CSB-RA025166MA1HU）靶向四跨膜蛋白家族成員TSPAN8，該蛋白通過介導膜蛋白復合物組裝參與細胞黏附、遷移及信號轉導調控，在多種腫瘤微環境及病理過程中發揮重要作用。本抗體采用重組單克隆技術制備，經ELISA嚴格驗證，在1:5000至1:50000稀釋范圍內表現出高親和力與特異性，可精準識別天然構象的TSPAN8蛋白。其高批次穩定性確保實驗重復性，適用于基礎科研領域中的蛋白表達定量分析，如通過ELISA技術檢測細胞裂解液或重組蛋白樣本中的TSPAN8水平。在腫瘤生物學研究中，該抗體可用于探索TSPAN8在癌細胞侵襲轉移、上皮間質轉化（EMT）過程中的分子機制，或結合體外模型研究其與整合素等相互作用網絡的調控功能。本產品為科研人員提供可靠工具，助力于癌癥相關信號通路及細胞表面標記物的功能研究。
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Uniprot No.：
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基因名：
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別名：anti TSPAN8 antibody; CO029 antibody; Tetraspanin 8 antibody; Tetraspanin-8 antibody; TM4SF3 antibody; Transmembrane 4 superfamily member 3 antibody; TSN8_HUMAN antibody; Tspan 8 antibody; Tspan-8 antibody; TSPAN8 antibody; TSPAN8 antibody antibody; Tumor associated antigen CO 029 antibody; Tumor-associated antigen CO-029 antibody
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反應種屬：Human
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免疫原：Recombinant Human TSPAN8 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號：7D4
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:5000-1:50000 FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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基因功能參考文獻：
- TSPAN8 mediated Wnt/beta-catenin pathway through binding to NOTCH2. The role of TSPAN8 in the drug resistance of gastric cancer. PMID: 29345284
- these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin, EGFR and CD44 appear as likely candidates. PMID: 28418857
- Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder. PMID: 28777493
- Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression PMID: 27270327
- LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo. PMID: 27375018
- Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 as a negative regulator of ILK activity. PMID: 28188308
- TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
- Knocking down TSPAN8 in AEG-1-overexpressing human hepatocellular carcinoma (HCC) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice PMID: 27339400
- Knockdown and knockout models revealed that CD151 and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review] PMID: 28408484
- Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation. PMID: 27996312
- TSPAN8 is involved in tumor progression and is an independent prognostic classifier in patients with gastric cancer. PMID: 25711980
- This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR) in both androgen-dependent and androgen-independent prostate cancer cell lines PMID: 26649804
- Our data suggest that TSPAN8-LEL may play an important role in mCRC cell invasion, and that the antibody we have developed could be a useful tool for inhibiting the invasion of TSPAN8-expressing mCRCs. PMID: 26562525
- Based on nasopharyngeal TSPAN8 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
- Tspn8 was over-expressed in multiple clinical malignant glioma tissues, and its expression level correlated with the grade of tumors. PMID: 25680464
- CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions. PMID: 22679508
- PMA-induced Tspan8-internalization promotes cell migration, but reduces matrix and cell adhesion. PMID: 20937409
- High TSPAN8 is associated with melanoma invasiveness. PMID: 21081927
- claudin-7-associated EpCAM is recruited into (tetraspanin-enriched membrane microdomains) and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation PMID: 17579117
- overexpression of TM4SF3 in esophageal cancer conferred advantage to the invasion and metastasis of this destructive disease PMID: 18365756
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Tetraspanin (TM4SF) family
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組織特異性：Gastric, colon, rectal, and pancreatic carcinomas.
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