PTX3 Recombinant Monoclonal Antibody

說明書

中文名稱：

PTX3重組抗體
貨號：

CSB-RA984883A0HU
規格：

￥1320
圖片：
Overlay Peak curve showing A549 cells stained with CSB-RA984883A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA984883A0HU PTX3重組單克隆抗體是針對長正五聚蛋白3（Pentraxin 3）靶點研發的高特異性科研工具。PTX3作為急性期反應蛋白家族成員，在先天免疫應答、炎癥調控及組織修復中發揮重要作用，其表達水平與感染性疾病、心血管病變等病理過程密切相關。本抗體經ELISA和流式細胞術（FC）雙重驗證，在FC應用中推薦使用1:50-1:200稀釋比例，可精準識別天然構象的PTX3蛋白，適用于細胞表面或胞內靶標檢測。實驗數據顯示其在不同細胞模型及重組蛋白體系中均表現出優異的結合能力與批次穩定性，可為炎癥信號通路研究、免疫細胞功能分析及心血管疾病分子機制探索提供可靠支持。該產品適用于體外實驗場景，包括但不限于：通過流式技術解析免疫細胞中PTX3的動態表達，利用ELISA平臺定量檢測培養上清或生物樣本中的蛋白含量變化，以及結合細胞實驗探究PTX3在病原體識別、血管生成等生物學過程中的調控作用。
Uniprot No.：

P26022
基因名：

PTX3
別名：

Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14), PTX3, TNFAIP5 TSG14
反應種屬：

Human
免疫原：

A synthesized peptide derived from human PTX3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

10D9
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:50-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
基因功能參考文獻：
1. PTX3 might be an early marker of cardiovascular mortality in patients with advanced chronic kidney disease yet before the increase of specific marker for systemic inflammation like hsCRP. PMID: 28377558
2. These findings reveal that the CRP- and PTX3-binding characteristics of FHL-1 differ from those of FH, likely underpinning independent immune regulatory functions in the context of the human retina. PMID: 29374201
3. given that acute aerobic exercise reduced the ex vivo production of PTX3 in both groups PMID: 28440716
4. PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy. PMID: 29949524
5. Patients with TAO showed increased presence of PTX3 in orbital tissue and serum. PMID: 29675428
6. Data show that pentraxin-3 (PTX3) is not a biomarker of disease activity and cannot be used for the purpose. PMID: 28043168
7. PTX3 is positively regulated by chronic hyperglycemia but negatively regulated by aldosterone PMID: 29715313
8. treatment of human osteoblast primary cultures derived from young patients with anti-PTX3 antibody, osteoblasts lost the morphological and molecular features typical of mature osteoblasts, acquiring fibroblast-like shape and highly decreasing nuclear factor kappa-B ligand (RANKL) and RUNX2 expression. PMID: 29022895
9. High PTX3 expression is associated with endothelial dysfunction during hemodialysis. PMID: 27915246
10. PTX3 might be an inflammatory biomarker for coronary artery disease. PTX3 was associated with the severity of coronary artery stenosis. PMID: 28778748
11. plasma level increased as pregnancy progressed PMID: 28421853
12. Results showed that increased PTX3 expression was significantly associated with tumor grade in human cervical cancer cells. It also demonstrated that PTX3 contributes to tumorigenesis and metastasis of cervical cancer cells. PMID: 27377307
13. serum level increased in pre-eclampsia PMID: 28569615
14. serum PTX-3 level might be a significant mediator in childhood-onset systemic lupus erythematosus (cSLE); the results support that PTX3 reflects active cutaneous vasculitis in cSLE and correlates with disease activity. PMID: 28420068
15. Serum PTX3 is related to the severity of autoimmune hepatitis, the presence of acute-on-chronic liver failure and 90-day mortality. PMID: 28809733
16. Knocking down long pentraxin-3 (PTX3) or vimentin repressed oleate-induced head and neck squamous cell carcinomas (HNSCCs) invasion. PMID: 28489600
17. Higher levels of PTX3 in women with preeclampsia were significantly associated with signs of adverse arterial effects during pregnancy. PMID: 28377191
18. PTX3 is associated with bacterial infection in patients with COPD. PMID: 28458531
19. Suggest that PTX3 plasma level at graft-versus-host disease occurrence is a robust onset biomarker and correlates with both maximum disease severity and response to corticosteroid treatment. PMID: 27893415
20. Plasma PTX3 level was elevated at the early stage of the exercise training intervention, and was subsequently associated with training-induced alteration of arterial stiffness in middle-aged and older adults. PMID: 26467819
21. White coat hypertension is characterized by increased PTX-3 levels. PMID: 26040439
22. Serum PTX3 concentrations are correlated with diabetic nephropathy. PMID: 27233528
23. Data show that miR-29c-3p and PTX3 are inversely correlated in tissues and meningioma cells, suggesting that PTX3 can be regulated by miR-29c-3p. PMID: 28327132
24. Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of rheumatoid arthritis. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the rheumatoid arthritis. PMID: 27152709
25. High PTX3 expression is associated with lung graft dysfunction. PMID: 27421969
26. JAK2V617F mutation influences myeloproliferative neoplasm -associated inflammation with a strong correlation between allele burden and PTX3 levels. Plasma levels of hs-CRP and PTX3 might be of prognostic value for patients with ET and PV PMID: 28228104
27. This study demonstrated that PTX3 plays an important role in glioma cell proliferation and invasion, and may thus serve as a novel potential therapeutic target in the treatment of gliomas. PMID: 27278519
28. PTX-3 blood level valuably discriminates the different stages of sepsis severity during the first week of intensive care treatment. PMID: 28793880
29. abundance is stimulated, in part, through AKT- and nuclear factor kappaB (NF-kappaB)-dependent pathways and that presence of PTX3 is necessary for PI3K-induced stem cell-like traits. PMID: 28223411
30. This is the first study showing that adolescent male swimmers have higher PTX3 levels than sedentary controls and that there is a linear relationship between PTX3 and GDF-15. PMID: 28664745
31. These findings provide evidence supporting the role of PTX3 as a mediator of the anti-inflammatory response in physiologically relevant conditions, and suggests that PTX3 counter regulates the development of atherosclerosis by enhancing the production of IL-10. PMID: 27450429
32. Endothelium, when exposed to high density circulating angiogenic cells, releases PTX3 which markedly impairs the vascular regenerative response in an autocrine manner. PMID: 27659714
33. Serum PTX3 levels were higher in non-obese rheumatoid arthritis patients than in obese. PMID: 27404695
34. PTX3 concentrations were significantly higher in the adrenal tumor group compared with the control group. PTX3 concentrations were positively correlated with carotid intima media thickness, systolic and diastolic blood pressure, and urinary metanephrine concentrations. Serum PTX3 concentrations increased in both functional and nonfunctional adrenal tumors. PMID: 28332877
35. patients with inflammatory rheumatic diseases have increased s-PTX3 levels, which, in contrast to other inflammatory markers, do not seem to improve within 6 months of therapy with methotrexate and/or anti-TNF. PMID: 28225768
36. median serum PTX3 is lower in systemic lupus erythematosus patients (especially when IFN-alpha is detectable) compared to blood donors PMID: 28257596
37. PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells. PMID: 27621420
38. PTX3 levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge. PMID: 27567326
39. Data suggest that modest weight loss in overweight adults due to caloric restriction and exercise decreases serum leptin (LEP) and high molecular weight adiponectin (ADPN), and increases serum pentraxin-3 (PTX3) in a manner that correlates with increased insulin sensitivity. PMID: 27605038
40. IL-6 trans-signaling and PTX3 amplification at the site of inflammation could have a role in pathophysiological mechanisms of Peyronie's disease. PMID: 28359407
41. Serum/plasma levels of PTX3 in autoimmune diseases were higher than in normal controls. PMID: 27255354
42. The genotype frequencies of rs2305619 and rs2120243 differed significantly between the Diabetic Nephropathy and the Non Diabetic Nephropathy groups. Patients with the GG variant of rs2305619 showed 4.078-fold higher susceptibility to DN than those with the AA variant (OR=4.078, 95% CI=1.370-12.135, p=0.012); patients with AA variant of rs2120243 had a lower risk of developing DN (OR=0.213, 95% CI=0.055-0.826, p=0.025). PMID: 28119515
43. We show that PTX3 levels correlate with the severity of aGVHD, cGVHD, and-with reservations-survival in patients undergoing allogeneic HSCT. PMID: 27403536
44. a decrease in FGF 2 is not accompanied by increased serum pentraxin 3 levels in patients with systemic sclerosis PMID: 27878407
45. PTX3 was higher in obese cases than controls (p = 0.0001). Eighty percent of the cases had Nonalcoholic Fatty Liver Disease with progressive increases in PTX3 levels as the severity of fatty liver increased (p = 0.0001). PMID: 27309736
46. PTX3 is an independent prognostic indicator in colorectal cancer. PMID: 27568661
47. CC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier ), and the same was found in the analysis of the T allele. PMID: 27538101
48. The level of plasma PTX3 in neonates with pulmonary arterial hypertension appears higher than those without the same diagnosis. PMID: 27838407
49. Within the limitations of this study, the results seem to sustain the involvement of Pentraxin 3 and Thrombospondin 1 in the processes of inflammation and angiogenesis in wound healing of patients with postorthodontic gingivectomy. PMID: 27403446
50. NF-kappaB signaling pathway may serve as potential targets for regulation of PTX3 expression in the retina. PMID: 27980366
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 9692

OMIM: 602492

KEGG: hsa:5806

STRING: 9606.ENSP00000295927

UniGene: Hs.591286

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