INHBB Recombinant Monoclonal Antibody

說明書

中文名稱：

INHBB重組抗體
貨號：

CSB-RA990624A0HU
規格：

￥1320
圖片：
Overlay Peak curve showing A549 cells stained with CSB-RA990624A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA990624A0HU INHBB重組單克隆抗體是針對抑制素β B亞基（INHBB）開發的高特異性科研工具。該抗體靶向的INHBB是TGF-β超家族重要成員，通過與α亞基組合形成激活素或抑制素二聚體，參與調控生殖激素分泌、卵泡發育及細胞增殖分化等關鍵生物學過程。本產品經ELISA和流式細胞術（FC）嚴格驗證，在推薦稀釋度（FC 1:50-1:200）范圍內展現優異的抗原結合能力與批次穩定性，可精準識別天然構象及重組表達的INHBB蛋白。適用于研究卵巢功能異常、睪丸發育障礙等生殖系統相關疾病的分子機制，亦可用于分析胚胎干細胞分化、組織再生修復中TGF-β信號通路的調控網絡。該抗體為研究配子發生、性腺穩態維持及腫瘤微環境中的細胞互作提供可靠檢測手段，特別推薦用于體外細胞模型、原代細胞培養物及生物樣本中INHBB蛋白的定量分析與細胞定位研究。
Uniprot No.：

P09529
基因名：

INHBB
別名：

Inhibin beta B chain (Activin beta-B chain), INHBB
反應種屬：

Human
免疫原：

A synthesized peptide derived from Human INHBB
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

34B10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:50-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
基因功能參考文獻：
1. Results found that INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues, and associated with lymph node metastasis. Further data revealed that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF-beta signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis . PMID: 30151927
2. Presence of varicocele was associated with lower serum inhibin B. PMID: 27423503
3. Elevated activin B levels together with normal activin A levels identified patients with the diagnostic symptoms of chronic fatigue syndrome/myalgic encephalomyelitis. PMID: 28302133
4. Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells. PMID: 27620967
5. Low activin B level is associated with tubal ectopic pregnancy. PMID: 26968108
6. Pregnant Han Chinese women carrying the rs7579169 CC genotype and G-G-C haplotype are significantly more likely to develop pre-eclampsia, especially late-onset and multiparous cases. PMID: 26313529
7. We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung. PMID: 25361680
8. reduction of RhoA signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma. PMID: 25343250
9. inhibin B and anti-Mullerian hormone serum concentrations did not provide an additional diagnostic tool for male infertility PMID: 25581422
10. inhibin B levels, but not FSH, are increased in primary hypothyroidism, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis PMID: 23692058
11. There are significant differences in serum inhibin B levels in patients with diminished ovarian reserve before and after supplementation with dehydroepiandrosterone (DHEA). PMID: 23664458
12. Inhibin B production was decreased following recombinant human chorionic gonadotropin administration in both control and polycystic ovary syndrome women. PMID: 24188875
13. Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range. PMID: 23349064
14. Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH) is a suitable surrogate for determination of sperm concentration in a semen sample. PMID: 23423746
15. The signaling pathway responsible for hepcidin up-regulation in the inflammatory context is still not understood completely. Activin B has an unexpected but crucial role in the induction of hepcidin by inflammation. PMID: 22611157
16. A genome-wide association study for preeclampsia in unrelated Australian individuals of Caucasian ancestry was performed to genotype single nucleotide polymorphisms the Inhibin, beta B gene on 2q14.2, in preeclampsia and normal pregnancy controls. PMID: 22432041
17. inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. PMID: 21938679
18. Compared with antimullerian hormone (AMH), stimulated serum inhBB is a more accurate predictor of ovarian response in patients undergoing in vitro fertilization. PMID: 21843890
19. Inhibin B constitutes a reliable marker of Sertoli cell function as well as spermatogenesis, while the clinical significance of anti-Mullerian hormone in men with varicocele remains to be elucidated. PMID: 21285453
20. High inhibin beta B is associated with cervical intraepithelial neoplasia grades 1 and 2 compared to cervix uteri. PMID: 21475087
21. Inhibin B and antimullerian hormone have a role in gonadal function after treatment for medulloblastoma or posterior fossa ependymoma during childhood PMID: 21168856
22. A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome. PMID: 20630504
23. The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. PMID: 20713036
24. Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low. PMID: 20149358
25. Antral follicle size influences serum inhibin B and FSH levels and alters their expected relationship with the number of antral follicles on day 3 PMID: 19061996
26. Gonads in anorexia nervosa with weight gain have low level of activity. Inhibin B is early marker of gonadal activity, and with weight gain, awakening of the reproductive function is gradual. PMID: 15070953
27. Inhibin B pubertal surge is prominent signal of gonadal maturation in females as well as in males. Significantly higher in boys than in girls. Review. PMID: 15319819
28. The expression of inhibin betaB by Sertoli cells is dependent on the coexistence of spermatogenic activity within these seminiferous tubules and is low in patients with Sertoli cell only syndrome. PMID: 15551748
29. Ovulatory cycles were characterized by higher FSH and lower inhibin B leveels in hypergonadotropic hypogonadism or premature ovarian failure. PMID: 15562017
30. Regular increase of inhibin B(InhB) during puberty. In first phases of gonadal maturation, InhB and FSH correlate positively, while in mid-late stages relationship is inverse. In mid-puberty (G3-G4), serum InhB increases. PMID: 15757857
31. Exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis. PMID: 15910540
32. inhibin B may have a role in male fecundity PMID: 16024538
33. INHBB expression was high in human adipocytes, reduced by weight loss and adipose tissue INHBB mRNA levels correlated to metabolic risk factors. PMID: 16650820
34. A significant down-regulation of inhibin-beta (B) subunit in extravillous trophoblast cells in IUGR syncytiotrophoblast cells was demonstrated. PMID: 16670820
35. Preoperative serum inhibin B concentration could not reliably predict a response to varicocelectomy, but the increase in inhibin B levels after treatment might suggest an improvement in testicular function. PMID: 16728349
36. Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours PMID: 16935389
37. The present findings showed that treatment with vaginal estroprogestinic decreases serum inhibin A and inhibin B levels, the follicular diameter PMID: 16989826
38. Varicocele sclerotherapy improves inhibin B levels and seminal parameters. PMID: 17376219
39. it is not clear that inhibin B does not seem to play any role in the mechanism of action of laparoscopic ovarian diathermy [letter] PMID: 17525068
40. Granulosa cell production of inhibin B is reduced by pharmacologically induced increase in the intrafollicular androgen levels. PMID: 17628551
41. decreased levels of inhibin b are associated with hot flushes, aches, joint pain, stiffness and depressed mood in the stages of menopausal transition. PMID: 17666595
42. Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies PMID: 17761145
43. Activin and estrogen crosstalk regulates transcription in human breast cancer cells. PMID: 17914098
44. Used monoclonal antibody to xenopus laevis Inhbb in ELISA for detection of human Inhbb. PMID: 17991484
45. Expression of the beta-B subunit is related to decidualization and can be detected in the circulation as activin B. PMID: 18381568
46. The degree of inhibin B increment during controlled ovarian stimulation provides a way for for predicting ovarian response to ovarian stimulation. PMID: 18555227
47. There was no significant association of (log)inhibin B profiles with age at final menstrual period. PMID: 18593767
48. Functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. PMID: 18927237
49. Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response. PMID: 19198021
50. Inhibin B is more potent than inhibin A in suppressing FSH in vitro and in vivo, and this difference in bioactivity is not explained by its affinity to betaglycan or activin type II receptors. PMID: 19589860
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亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
數據庫鏈接：

HGNC: 6067

OMIM: 147390

KEGG: hsa:3625

STRING: 9606.ENSP00000295228

UniGene: Hs.1735

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