IL34 Recombinant Monoclonal Antibody

說明書

中文名稱：

IL34 Recombinant Monoclonal Antibody
貨號：

CSB-RA751146MA1HU
規格：

￥1320
圖片：
Overlay Peak curve showing MCF-7 cells stained with CSB-RA751146MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG1 (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q6ZMJ4
基因名：

IL34
別名：

C16orf77 antibody; Chromosome 16 open reading frame 77 antibody; FPT025 antibody; IL 34 antibody; IL-34 antibody; Il34 antibody; IL34_HUMAN antibody; Interleukin 34 antibody; Interleukin-34 antibody; Interleukin34 antibody; MGC34647 antibody
反應種屬：

Human
免疫原：

Recombinant Human IL34 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

17G7
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:50-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
基因功能參考文獻：
1. Study found that high IL-34 levels in synovial fluid were significantly associated with the radiographic and symptomatic severity of knee osteoarthritis. PMID: 30159102
2. Data showed that single expression of M-CSF or IL-34 can be observed in lung cancer tissues and correlated with poor survival. Additionally, their high co-expression correlates with disease stages and poor survival. Thus, evaluating the expression of both M-CSF and IL-34 may help to estimate disease progression and malignant degree in lung cancer patients. PMID: 29323162
3. this study shows that IL-34 regulates IL-6 and IL-8 production in human lung fibroblasts via MAPK, PI3K-Akt, JAK and NF-kappaB signaling pathways PMID: 29857241
4. Study indicates that IL-34 can be an indicator of liver inflammation and fibrosis in patients with chronic hepatitis B virus infection. PMID: 29599606
5. In conclusion, elevated serum IL-34 levels were demonstrated to be independently associated with renal insufficiency and coronary artery disease in patients with chronic heart failure, regardless of the systolic function. PMID: 27982136
6. Data indicate that the interleukin 34 (IL-34) is a feasible diagnostic marker of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients. PMID: 27363523
7. Findings uncover a novel function for IKKbeta/mHTTx1 interactions in regulating IL-34 production, and implicate a role for IL-34 in non-cell-autonomous, microglial-dependent neurodegeneration in HD. PMID: 28973132
8. The IL-34/STAT3/miR-21 pathway is crucial for the survival of synovial fibroblasts in rheumatoid arthritis PMID: 27084907
9. Data show that both serum interleukin-34 (IL-34) and IL-34 mRNA in mononuclear leukocytes (PBMCs) in chronic hepatitis B virus (HBV) patients was significantly decreased compared to the healthy controls. PMID: 28614380
10. pathogenic role for IL34 in mediating immunosuppression and chemoresistance and identify it as a tractable target for anticancer therapy. PMID: 27550451
11. The current study aimed to assess the IL-34 expression in response to two members of the transforming growth factor (TGF)-beta family, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from rheumatoid arthritis patients. PMID: 27865758
12. The receiver operating characteristic (ROC) curve analysis has shown that IL-34 has more discriminatory power than C-reactive protein (CRP) for the risk of diabetic complications. The cut-off value for IL-34 was established as 91.2 pg/mL. The gist of our research was identification of IL-34 as an additional potential inflammatory biomarker for the prediction of the risk of vascular diabetic complications. PMID: 26849008
13. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis PMID: 26754294
14. findings demonstrated that M-CSF binds to IL-34; molecular docking studies predicted the formation of a heteromeric M-CSF/IL-34 cytokine PMID: 26095744
15. These results suggest that IL-34, a novel osteoclastogenic cytokine, plays a role in rheumatoid arthritis-associated joint damage and is a potential biomarker for predicting subsequent radiographic progression in patients with RA. PMID: 25027626
16. IL-34 is expressed by human FOXP3+CD45RCloCD8+ and CD4+ Tregs and markedly inhibited alloreactive immune responses. PMID: 26389674
17. This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation. PMID: 25662098
18. In vitro and in vivo experiments indicate that IL-34 expression is regulated by TNF-a and IL-1b and that its overexpression is associated with an increase in osteosarcoma growth and metastasis. PMID: 25471534
19. the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in inflammatory bowel disease PMID: 25896238
20. IL-34 is up-regulated in inflammatory bowel disease and suggest a role for this cytokine in sustaining the inflammatory responses in this disease PMID: 25800277
21. IL-34 is induced by IL-22 in the inflammatory cascade in response to IAV infection. PMID: 25415279
22. IL-34 expression in human gingival fibroblasts, stimulated by TNF-alpha and IL-1beta PMID: 24339952
23. potent profibrotic factor in hepatitis C virus liver fibrosis PMID: 25066464
24. IL-34 is associated with insulin resistance. PMID: 24712570
25. IL-34 promotes the development, survival, and function of microglia and Langerhans cells; therefore, this cytokine may predominately function in brain and skin biology.[review] PMID: 24737461
26. Circulating IL-34 levels in rheumatoid arthritis correlated with autoantibody production. PMID: 23996288
27. This study is the first to illustrate downstream transcriptional profiles and pathways of IL-34 in comparison with CSF-1 and identify notable differences in CCR2 expression. PMID: 23684409
28. These findings suggest that IL-34 may play a role in the pathogenesis of rheumatoid arthritis. PMID: 23421370
29. Data suggest that CSF-1R-independent actions of IL-34 via receptor-type protein-tyrosine phosphatase zeta (PTP-zeta) might be considered in evaluating IL-34 roles in development and disease. PMID: 23744080
30. the feline CSF-1R was cloned and the responsiveness to CSF-1 and IL-34 from a range of species, was examined. PMID: 23260168
31. IL-34 levels were significantly increased in patients with coronary artery disease (CAD), and positively correlated with hs-CRP levels, suggesting that IL-34 may be an independent predictor of CAD. PMID: 23206468
32. IL-34 as a nonredundant cytokine for the development of Langerhans cells during embryogenesis as well as for their homeostasis in the adult skin. PMID: 23177320
33. Data suggest a discrete role of IL-34 in inflammatory rheumatoid arthritis (RA) diseases. PMID: 22264405
34. study identifies IL-34 expression in the synovial tissue of patients with arthritis; this cytokine, as a downstream effector of TNFalpha and IL-1beta, may contribute to inflammation and bone erosions in rheumatoid arthritis PMID: 22039170
35. The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. PMID: 20504948
36. Discovered IL-34 and its receptor CSF1 by functional screening of the extracellular proteome. PMID: 18467591
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亞細胞定位：

Secreted.
蛋白家族：

IL-34 family
組織特異性：

Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate
數據庫鏈接：

HGNC: 28529

OMIM: 612081

KEGG: hsa:146433

STRING: 9606.ENSP00000288098

UniGene: Hs.461214

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