GIPR Recombinant Monoclonal Antibody
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中文名稱：GIPR重組抗體
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貨號(hào)：CSB-RA009438MA2HU
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規(guī)格：￥1320
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圖片：
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Western Blot
Positive WB detected in:Hela whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate
All lanes: GIPR antibody at 1:1000
Secondary
Goat polyclonal to human IgG at 1/50000 dilution
Predicted band size: 54 kDa,49 kDa,50 kDa
Observed band size: 54 kDa
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA009438MA2HU GIPR重組單克隆抗體是針對(duì)胃抑制多肽受體（GIPR）開發(fā)的高特異性科研工具，該靶點(diǎn)屬于G蛋白偶聯(lián)受體（GPCR）家族，在調(diào)節(jié)胰島素分泌、能量代謝及脂肪儲(chǔ)存中發(fā)揮重要作用，與2型糖尿病、肥胖等代謝性疾病密切相關(guān)。本抗體通過重組技術(shù)制備，具有高批次一致性，經(jīng)嚴(yán)格驗(yàn)證可應(yīng)用于酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）和蛋白質(zhì)免疫印跡（WB），其中WB實(shí)驗(yàn)推薦使用1:500至1:5000的稀釋范圍，實(shí)驗(yàn)結(jié)果可呈現(xiàn)清晰的特異性條帶。該產(chǎn)品適用于探索GIPR在代謝調(diào)控中的分子機(jī)制、評(píng)估受體表達(dá)水平變化及其與疾病關(guān)聯(lián)性研究，也可為開發(fā)靶向GIPR通路的新型干預(yù)策略提供實(shí)驗(yàn)支持，廣泛應(yīng)用于細(xì)胞生物學(xué)、分子病理學(xué)及藥理研究等領(lǐng)域，為科研人員提供可靠的數(shù)據(jù)支持。
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Uniprot No.：
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基因名：
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別名：Gastric inhibitory polypeptide receptor, GIPR
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反應(yīng)種屬：Human
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免疫原：Recombinant Human GIPR protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Human IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：32C2
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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基因功能參考文獻(xiàn)：
- an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
- Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
- GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
- Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
- The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
- Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
- The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
- Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
- GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
- GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
- GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
- This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
- Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
- Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
- Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
- Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
- Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
- The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
- a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
- Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
- Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
- Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
- differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
- Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
- Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
- the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
- GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
- GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
- Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
- Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
- Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 2 family
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