FDPS Recombinant Monoclonal Antibody
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中文名稱：FDPS重組抗體
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貨號：CSB-RA029525A0HU
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規格：￥1320
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圖片：
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Overlay Peak curve showing HepG2 cells stained with CSB-RA029525A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他：
產品詳情
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產品描述：CSB-RA029545A0HU是專為科研設計的FDPS重組單克隆抗體，靶向法尼基焦磷酸合酶（FDPS）這一關鍵代謝調控蛋白。FDPS作為甲羥戊酸通路的核心酶，通過催化焦磷酸法尼酯的合成，參與膽固醇生物合成和蛋白質異戊烯化修飾，在腫瘤細胞增殖、骨代謝調節及細胞信號轉導中發揮重要作用。本產品經ELISA和流式細胞術（FC）雙重驗證，在FC應用中推薦采用1:50-1:200的稀釋比例，可實現對內源性FDPS蛋白的特異性識別。其高靈敏度和精準的結合能力，配合嚴格的交叉反應性測試及批次間一致性質控，確保實驗數據的可靠性。該抗體適用于探索FDPS在腫瘤發生發展中的分子機制、骨代謝異常相關疾病研究，以及基于細胞模型的甲羥戊酸通路功能分析等科研領域，為體外檢測細胞表面或胞內FDPS表達水平提供高效工具，尤其適用于腫瘤細胞系篩選、藥物靶點驗證及代謝通路調控研究。
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Uniprot No.：
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基因名：FDPS
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別名：Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase), FDPS, FPS KIAA1293
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反應種屬：Human
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免疫原：A synthesized peptide derived from Human FDPS
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：12H4
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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基因功能參考文獻：
- Farnesyl pyrophosphate (FPP) allosterically regulated the activity of farnesyl pyrophosphate synthase. PMID: 28098152
- FPPS mediates TGF-beta1-induced lung cancer cell invasion and epithelial-to-mesenchymal transition via the RhoA/Rock1 pathway. PMID: 29337059
- Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase PMID: 29036218
- These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme. PMID: 25630225
- our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels. PMID: 24534219
- Results suggest that polymorphisms of the FDPS gene may influence the bone response to drugs targeting the mevalonate pathway, like statins. PMID: 24311107
- A co-crystal structure of human farnesyl pyrophosphate synthase in complex with a bisphosphonate and two molecules of inorganic phosphate. PMID: 24598914
- The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiinfective drug leads. PMID: 24927548
- These observations suggest that an increase in the expression of endogenous FPPS could confer at least partial resistance to the pharmacological effect of N-BP drugs such as ZOL in vivo PMID: 24369118
- LRP5 and FDPS loci age-specifically affect skeletal traits in healthy fertile women. PMID: 23238007
- Data indicate compounds represent a new structural class of farnesyl pyrophosphate synthase (hFPPS) inhibitors and suggest a development of therapeutics. PMID: 23998921
- The iPA-driven modulation of FDPS can cause an enhancement of post-translational prenylation essential for the biological activity of key proteins in NK signaling and effector functions, such as Ras. PMID: 23847096
- FPPS was more highly expressed in prostate cancer vs. normal prostate tissue. The association of FPPS with established histopathological risk parameters and biochemical recurrence implicates a contribution of the mevalonate pathway to PC progression. PMID: 22407328
- FPPS might play an important role in Ang II-induced cardiac hypertrophy and fibrosis in vivo, at least in part through RhoA, p-38 MAPK and TGF-beta1. PMID: 23277274
- The crystal structure of human FPPS in complex with a novel bisphosphonate YS0470 and in the absence of a second substrate showed partial ordering of the tail in the closed conformation. PMID: 23234314
- Common polymorphisms of the FDPS gene influence the response to bisphosphonates in osteoporotic women. PMID: 21151198
- findings reveal a FDPS-dependent mechanism in the internalization and down-regulation of beta2AR, identify FDPS as a potential target for improving the therapeutic efficacy of beta-agonists PMID: 22278941
- first study on the gene FDPS rs2297480 SNP in postmenopausal Thai women.The effect did not contribute to the baseline of bone mineral density nor bone turnover markers. PMID: 22338925
- The A/C rs2297480 polymorphism of FDPS was highly differently distributed among osteonecrosis-of-the-jaw patients and controls, with a correlation between AA carrier status and occurrence of ONJ after 18-24 months of treatment with bisphosphonates. PMID: 21196316
- characterized the sterol-response-element-binding protein 2 and nuclear factor Y-binding site in the farnesyl diphosphate synthase promoter PMID: 20450493
- This study provides the first evidence of the presence of FPPs activity in human CRC. Moreover, FPPs enzyme was found to play a significant role in colon cancer proliferation. PMID: 15713990
- mitochondrial targeting of FPS may be widespread among eukaryotes PMID: 17198737
- findings suggest that a single nucleotide polymorphism in the FDPS gene (rs2297480) may be a genetic marker for lower bone mineral density in postmenopausal Caucasian women PMID: 17368768
- FDPS is involved in the resistance to zoledronic acid of osteosarcoma cells. PMID: 18494934
- characterized functionally the minimal basal promoter of the human FDPS gene by means of deletion mutants and we have identified two cis-acting elements which modulate the FDPS gene expression and are recognized by Pax5 and OCT-1 transcription factors PMID: 19056481
- FPPS knockdown cells activated Vgamma9Vdelta2 T cells, as measured by increased levels of CD69 and CD107a, killing of FPPS knockdown cells, and induction of IFN-gamma secretion PMID: 19494338
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相關疾?。?/div>Porokeratosis 9, multiple types (POROK9)亞細胞定位：Cytoplasm.蛋白家族：FPP/GGPP synthase family數據庫鏈接：
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