ENO2 Recombinant Monoclonal Antibody
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中文名稱：ENO2 Recombinant Monoclonal Antibody
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貨號：CSB-RA557656A0HU
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規格：￥1320
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圖片：
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Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA557656A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE), ENO2
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反應種屬：Human
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免疫原：A synthesized peptide from human ENO2 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：5G3
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.
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基因功能參考文獻：
- CgA and NSE are clinically valuable tumor markers in neuroblastoma and they merit prospective clinical evaluations as such. PMID: 29737901
- the major result was that elevated serum NSE appears to correlate with prognosis in advanced prostate cancer (PCa), particularly in patients with progressive and metastatic castration-resistant PCa. Based on the existing literature, the role of serum NSE in PCa patients should be further evaluated. PMID: 28885659
- Identify a possible cross-reactive conformational B cell epitope, shared by Borrelia enolase and gamma enolase, but not by alpha enolase. We hypothesize that this autoantibody interferes with glycolysis in neuronal cells, as the physiological basis for chronic symptoms in at least some cases of post-treatment Lyme disease syndrome. PMID: 29317049
- We investigated the possible correlation between TCD results and S100B, NSE and LDH levels as well as between NSE-LDH and S100B-LDH levels by regression analysis. We found a statistically significant relationship for both NSE, S100B with LDH. PMID: 29244749
- ENO2 promoted cell growth, glycolysis, and glucocorticoid resistance, all of which were effectively inhibited when ENO2 was silenced with shRNAs and up-regulated various glycolysis-related genes and enhanced Akt activity with subsequent glycogen synthase kinase3beta (GSK-3beta) phosphorylation, inducing cell proliferation and glycolysis. PMID: 29689546
- High Neuron-Specific Enolase expression is associated with poor response to therapy in small cell lung cancer. PMID: 28127669
- In neonates, NSE and s100B levels increase after bypass surgery and return below preoperative baseline levels by postoperative day seven. PMID: 28571730
- elevated preoperative NSE serum level is adverse predictive and prognostic indicator in adenosquamous lung carcinoma PMID: 27623437
- There is a significant correlation between mortality in the critically ill patients in the intensive care unit and increased serum concentration of S100B and NSE. PMID: 29222857
- The detection of TK1 combined with that of cytokeratin-19 fragment (CYFRA21-1), CEA or NSE increased the diagnostic value of TK1 for lung squamous cell carcinoma, adenocarcinoma and small cell lung cancer, respectively. PMID: 29247745
- Serum levels of neuron-specific enolase (and S100B) are both significantly increased postoperatively and predict postoperative cognitive dysfunction. PMID: 27433840
- This study indicates that serum neuron-specific enolase is elevated in diabetic ketoacidosis and correlated with the severity of hyperglycemia, ketosis, and acidosis. PMID: 28056586
- serum level elevated in small cell lung cancer patients with shorter progression-free survival PMID: 29145241
- Levels of NSE and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies. PMID: 27653032
- High NSE expression is associated with hypoxic-ischemic encephalopathy. PMID: 28931055
- we conducted a retrospective study to evaluate the correlation between clinical-pathological parameters, serum levels of neuron-specific enolase and CYFRA21-1, and bone metastases in lung cancer patients.Multivariate logistic regression analysis showed that patients' age concentrations of neuron-specific enolase and histopathological types were the independent risk factors for bone metastases in patients with lung cancer PMID: 28671048
- Suggest that NSE may be a practical parameter that can be used to monitor TB activity and treatment response. Elevated serum NSE level originates, at least in part, from macrophages in granulomatous lesions. PMID: 27271274
- HER2 and NSE serum levels were independent prognostic factors in patients with brain metastases in breast cancer. Serum HER2 and MMP-9 appear to be associated with BM in metastatic BC patients. Their predictive value for BM still needs to be evaluated in further prospective studies. PMID: 27464303
- this study shows that neuron-specific enolase level is both a predictive marker of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors treatment and a prognostic marker in non-small cell lung cancer harboring EGFR mutations patients PMID: 26719155
- The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset. PMID: 27495086
- High neuron-specific enolase expression is associated with poor response to chemotherapy in small cell lung cancer. PMID: 26886220
- In pregnant women developing preeclampsia, the levels of NSE remained high throughout pregnancy, compared to healthy women where the levels decline. PMID: 26355117
- Serum neuron specific enolase was a useful marker in predicting subclinical brain damage following essential hypertension. PMID: 27000243
- BALF and serum NSE, CEA, and CYFRA21.1 elevated in lung cancer, which had prompt value for pathology, especially significant for BALF. PMID: 27072263
- Significant levels of CEA, CYFRA 21-1, NSE, and TSGF were detected in the serum. The amounts found were useful for diagnosing non-small cell lung cancer (NSCLC) patients who depended on the currently limited biomarker development. PMID: 27072222
- higher serum and nasal secretion levels were measured in patients with chronic rhinosinusitis compared with healthy controls PMID: 26867533
- CEA, NSE, CA125 and pro-GRP could serve as biomarkers for SCLC, and CEA and CYFRA21-1 could serve as biomarkers for NSCLC. Pro-GRP, CA125 and CEA were related to the clinical stages of lung cancer PMID: 26560853
- Serum neuron-specific enolase level is an independent predictor of overall survival in patients with gastroenteropancreatic neuroendocrine tumors PMID: 26712902
- Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE. PMID: 26972711
- Elevation of neuron specific enolase and brain iron deposition is associated with beta-propeller protein-associated neurodegeneration. PMID: 26481852
- Data show that serum neuron-specific enolase, cytokeratin 19 fragment 21-1, pro-gastrin-releasing peptide, squamous cell carcinoma antigen, tissue inhibitor of metalloproteinase-1, and human epididymis protein 4 are not associated with brain metastases. PMID: 26730601
- Neuron specific enolase levels were not effective in predicting outcomes or detecting recurrences of Merkel cell carcinoma. PMID: 26299616
- This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. PMID: 26421286
- NSE values is the best predictors of poor 6-month outcome after out-of-hospital cardiac arrest PMID: 26324761
- Studied diagnostic Value of Serum Levels of GFAP, pNF-H, and NSE Compared With Clinical Findings in Severity Assessment of Human Traumatic Spinal Cord Injury. PMID: 25341992
- The association was studied of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) on S-100B and neuron-specific enolase (NSE) in severe traumatic brain injury (sTBI). PMID: 25518864
- In this study, the appearance of NeuN-positive cells were observed in the basal plate as early as 5 month of gestation. PMID: 25904356
- the present findings emphasize that S100 and NSE-immunopositivity might be useful for detecting the cause and process of death due to traumatic brain injury. PMID: 25211554
- Report ontogenic development of nerve fibers in human fetal livers using immunohistochemical detection of NCAM1/neurone-specific enolase expression. PMID: 25326085
- The use of serum NSE as a diagnostic marker for disability progression in multiple sclerosis was not supported. PMID: 25686504
- Serum neuron specific enolase levels were found significantly increased in acute stroke cases as compared to controls. PMID: 24838548
- Neuron-specific enolase levels were able to diagnose sepsis-associated encephalopathy but with less sensitivity than S100Beta. PMID: 24760429
- results suggested the use of serum S-100beta and NSE levels as indicators for brain injury PMID: 26040109
- High levels of neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCC) were detected in 306 (63.6%), 89 (18.5%) and 125 (26.0%) non-small cell lung cancer patients, respectively. PMID: 23712355
- The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning PMID: 24505052
- NSE expression is a viable biomarker for MM and can be a useful reference for the design and adjustment of clinical MM treatment programs. PMID: 24796851
- Serial NSE analysis during the acute period of ischemic stroke is useful for monitoring hemorrhagic transformation and the blood-brain barrier disruption status PMID: 25183561
- Serum NSE levels are closely associated with peripheral neuropathy in patients with diabetes. PMID: 23846809
- This is the first study to suggest blood NFL mRNA as a surrogate marker for early prediction of prediabetic peripheral neuropathy, while NSE mRNA levels may be of no diagnostic value in prediabetic patients. PMID: 24733614
- In patients treated with mild hypothermia after out of hospital cardiac arrest changes in NSE are more suitable than its absolute serum levels for the prediction of poor neurologic outcome. PMID: 23836424
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亞細胞定位：Cytoplasm. Cell membrane.
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蛋白家族：Enolase family
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組織特異性：The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
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數據庫鏈接：
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