CRP Recombinant Monoclonal Antibody

說明書

中文名稱：

CRP重組抗體
貨號：

CSB-RA988767A0HU
規格：

￥1320
圖片：
IHC image of CSB-RA988767A0HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.38% DAB.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA988767A0HU CRP重組單克隆抗體是針對人C-反應蛋白（C-Reactive Protein, CRP）研發的高特異性抗體，適用于ELISA和免疫組化（IHC）實驗。CRP是一種由肝臟合成的急性期反應蛋白，其血清濃度在炎癥、感染或組織損傷時顯著升高，通過與病原體或受損細胞表面的配體結合，激活補體系統并參與先天免疫調控。本抗體采用重組表達技術制備，具有嚴格的批次一致性和低交叉反應性，在ELISA實驗中表現出高靈敏度與線性檢測范圍；在IHC應用中可清晰定位石蠟包埋組織樣本中的CRP蛋白，推薦使用1:50至1:200稀釋度進行組織切片染色。該產品可廣泛應用于炎癥相關機制研究、心血管疾病模型分析、免疫應答評估等科研領域，為病理狀態下CRP的蛋白表達水平檢測及組織分布研究提供可靠工具。
Uniprot No.：

P02741
基因名：

CRP
別名：

C-reactive protein [Cleaved into: C-reactive protein(1-205)], CRP, PTX1
反應種屬：

Human
免疫原：

A synthesized peptide derived from Human CRP
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

10F7
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
基因功能參考文獻：
1. gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production. PMID: 29644527
2. Combinative index (arterial lactate, NT-proBNP and CRP) could serve as a valuable predictor for the 28-day mortality rate in patients with sepsis. PMID: 30158031
3. CRP rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing Systemic Lupus erythematosus PMID: 29556849
4. The study showed that higher CRP and lower T3 levels were associated with stroke severity on admission. Functional outcome is likely secondary to stroke severity but functional outcome at discharge was associated with higher CRP levels. PMID: 30056003
5. These findings reveal that the CRP- and PTX3-binding characteristics of FHL-1 differ from those of FH, likely underpinning independent immune regulatory functions in the context of the human retina. PMID: 29374201
6. Short-term changes in daily movement behaviour can affect salivary CRP, a marker of systemic inflammation. PMID: 29499122
7. M1 macrophages were characterized by elevated CRP mRNA expression (by 67%), CRP protein levels (by 108%), and upregulation of NFkappaB activation PMID: 29687414
8. Levels of CRP and PCT in CSF did not present greater accuracy in differentiating bacterial from viral meningitis compared to serum levels. PMID: 30143494
9. elevated serum C-reactive protein (CRP) is a well-known proxy for infections/immune abnormalities. Our results show elevated C-reactive protein levels to be associated with an increase in risk for schizophrenia. PMID: 29306175
10. High CRP expression is associated with Nonalcoholic fatty liver disease. PMID: 29402657
11. High C-reactive protein expression is associated with impaired glucose tolerance. PMID: 29078256
12. Findings indicate that childhood infections do not have an independent, lasting effect on circulating inflammatory marker levels subsequently in childhood; however, elevated inflammatory markers may be harmful for intellectual development/function. PMID: 29198208
13. maternal serum level has predictive value for chorioamnionitis PMID: 29430983
14. serum level elevated in preterm labor leading to preterm birth PMID: 29426269
15. Among healthy women attempting pregnancy after one or two pregnancy losses, elevated C-reactive protein is associated with reduced fecundability. PMID: 29317123
16. Suggest a close association between CRP and metabolic syndrome, while the association between the dietary inflammatory index and MetS was limited. PMID: 29954070
17. pre-procedural serum CRP could be a valuable predictor of global cardiovascular risk. PMID: 28128312
18. Data suggest that serum CRP levels show positive association with ChildTurcottePugh scores in subjects with liver cirrhosis; GSH levels show negative association with ChildTurcottePugh scores; thus, CRP and GSH appear to exert synergistic effects in association with severity of liver cirrhosis. This cross-sectional study was conducted in Taiwan. (GSH = glutathione) PMID: 29861471
19. Study shows for the first time that CRP activates signaling of integrin alpha2 via binding to integrin alpha2 and Fcgamma receptor I in breast cells and MDA-MB-231 triple-negative human breast cancer cells. PMID: 28846105
20. This meta-analysis suggests that C-reactive protein/albumin ratio (CAR)may be a potential prognostic marker in solid cancers PMID: 28128229
21. The results of the study suggest that the levels of C-reactive protein and tumor necrosis factor-alpha are important diagnostic markers of inflammation in patients with chronic pancreatitis and type 2 diabetes mellitus. PMID: 30280549
22. Elevated serum C-reactive protein could be a bacterial infection predictor in decompensated cirrhosis. PMID: 29384797
23. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of Cardiac biomarkers . Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. PMID: 29857573
24. Data suggest that C-reactive protein (CRP) may play an important role in the development of tongue squamous cell carcinoma (TSCC). PMID: 29385406
25. For WBC, N (%), and ESR, both groups showed similar patterns of temporal values 14 days after surgery regardless of preoperative CRP level. Our findings could be used as guidelines for patient discharge and during the follow-up period after surgery. PMID: 29854731
26. The neutrophil/lymphocyte ratio is a better addition to C-reactive protein than CD64 index as a marker for infection in COPD. PMID: 28185443
27. This retrospective cohort study aimed to identify the early postoperative kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in children undergoing tetralogy of Fallot (ToF) correction. PMID: 29111402
28. After beta-blocker treatment, hs-CRP levels are associated with functional capacity in heart failure patients. PMID: 29396658
29. Hypertensive patients with coronary tortuosity have a higher serum hs-CRP level concentration and have a higher incidence of lacunar infarction than hypertensive patients without coronary tortuosity. PMID: 29436255
30. High CRP expression is associated with non-small cell lung cancer. PMID: 29549910
31. T allele of rs1205 in CRP gene was protective against Takayasu arteritis in our patients. CC genotype was associated with involvement of coronary artery and ascending aorta. A trend toward a blunted CRP response seen in patients. PMID: 29024426
32. Serum C-reactive protein (and COMP) levels were both associated with the incidence of knee osteoarthritis. PMID: 29351749
33. coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors PMID: 29325799
34. Data suggest that C-reactive-protein (CRP) concentration is weakly associated with global DNA methylation level, and this association was more clearly in individuals with the minor allele of the 5,10-methylenetetrahydrofolate reductase (MTHFR)missense SNP rs1801133. PMID: 29439678
35. A longitudinal association between adolescent CRP levels and adult schizophrenia diagnosis indicates a potentially important role of inflammation in the pathogenesis of the illness PMID: 27622678
36. rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities PMID: 29379005
37. CRP levels predict the development of anastomotic leak and postoperative mortality after colorectal cancer surgery. PMID: 28132052
38. Uremia patients receiving maintenance hemodialysis with hospitalacquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP, IL2 and TNFalpha levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients. PMID: 29257244
39. High CRP expression is associated with cardiovascular disease. PMID: 28724840
40. The results of this meta-analysis suggest that increased CRP expression indicates a poorer prognosis in patients with bone neoplasms. PMID: 29668751
41. C-reactive protein (CRP) recognized 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) in the supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) monolayers without calcium at pH 7.4 and 5.5. PMID: 29172154
42. Used Ultra Performance Liquid Chromatography-Ultra Definition Mass Spectrometry-based proteomics to compare serum samples from 19 colorectal cancer (CRC) patients. The samples were first analyzed after dividing them into two categories based on CRP, CRP <30 and CRP >30, and the same samples were analyzed again after being divided into the categories short and long 5-year survival. PMID: 29630649
43. CRP bound to surface CD32 (also known as FcgammaRII) on myeloma cells, which activated a pathway mediated by the kinase p38 MAPK and the transcription factor Twist that enhanced the cells' secretion of osteolytic cytokines. PMID: 29233917
44. high-sensitivity C-reactive protein could have a role in recurrent stroke and vascular events in patients treated with statins PMID: 28302952
45. Procalcitonin and CRP serum levels are associated with the appearance of intra-abdominal infection after colorectal cancer surgery. PMID: 28918433
46. C-reactive protein polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, posttraumatic stress disorder, and C-reactive protein. PMID: 28867284
47. Elevated CRP level is correlated with poor prognosis in patients with metastatic renal cell carcinoma receiving tyrosine kinase inhibitors treatment. (Meta-analysis) PMID: 29080691
48. The study reveals that CRP might be a clear cell renal cell carcinoma development promoter. PMID: 28923830
49. CRP distinguished sepsis and non-septic ICU patients. PMID: 28898742
50. Suggest that hs-CRP may be a marker of comorbidities associated with worse health status in myocardial infarction. PMID: 28946036
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亞細胞定位：

Secreted.
蛋白家族：

Pentraxin family
組織特異性：

Found in plasma.
數據庫鏈接：

HGNC: 2367

OMIM: 123260

KEGG: hsa:1401

STRING: 9606.ENSP00000255030

UniGene: Hs.709456

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