CRABP2 Recombinant Monoclonal Antibody
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中文名稱：CRABP2 Recombinant Monoclonal Antibody
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貨號：CSB-RA566916A0HU
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規格：￥1320
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圖片：
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Western Blot
Positive WB detected in: HT-29 whole cell lysate(30μg), SH-SY5Y whole cell lysate(30μg)
All lanes: CRABP2 polymerase beta antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa
Exposure time：2min
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其他：
產品詳情
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Uniprot No.：
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基因名：CRABP2
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別名：Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II), CRABP2
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反應種屬：Human
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免疫原：A synthesized peptide from human CRABP2 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：12C12
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
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基因功能參考文獻：
- Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis PMID: 29378601
- These data suggest a retinoic acid-independent, non-tumor suppressor role of CRABP2 for the survival of Malignant peripheral nerve sheath tumor (MPNST) cells in vitro. Targeting CRABP2 overexpression may represent a unique approach for the treatment of human MPNST. PMID: 28502478
- A high expression ratio between FABP5 and CRABPII may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy. PMID: 27418530
- reducing CRABP2 levels may enhance the therapeutic index of Retinoic acid in glioblastoma multiforme patients PMID: 26893190
- in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo PMID: 26839961
- The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. PMID: 25320093
- CBX3 and CRABP2 expression was markedly increased in lung cancer tissues PMID: 24751108
- Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described PMID: 24059243
- CRABP2 controls mRNA stabilization by HuR. PMID: 24687854
- overexpression of CRABP-II is a late event of pancreatic carcinogenesis, and it could be used as a diagnostic marker PMID: 24709110
- all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
- E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC PMID: 23327868
- Hypermethylation in the CpG island of the CRABP2 gene is associated with astrocytic gliomas. PMID: 22275178
- Aberrant methylation in CRABP-II reduces the expression of CRABP-II that in turn confers retinoic acid resistance in medulloblastoma cells. PMID: 22153617
- Low CRABP2 is associated with pancreatic ductal adenocarcinoma. PMID: 22010213
- Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation PMID: 21998312
- Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure. PMID: 21605859
- Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation. PMID: 21414315
- Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis. PMID: 20308937
- Data sghow a higher frequency of CRABP2 and MX1 hypermethylation in primary HNSCC when compared with lymphocytes from healthy individuals. PMID: 20019841
- Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. PMID: 11909957
- Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of this protein PMID: 12482873
- In this study, we excluded mutations within the complete coding region and the promoter of LMNA and the CRABP II gene in HIV-1 infected patients with lipodystrophy PMID: 12844477
- CRABP-II has a role in wound re-epithelialisation by dermal fibroblasts PMID: 14766225
- Phosphorylation/dephosphorylation of retinoic x receptor alpha via protein kinase C may be involved in the regulation of CRABP-II gene expression. PMID: 15225641
- Data suggest that the ligand-controlled nuclear localization signal of CRABP-II may represent a general mechanism for posttranslational regulation of the subcellular distribution of a protein. PMID: 15866176
- Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased CRABPII expression in MDA-MB-231 cells PMID: 15870697
- CRABP-II overexpression in CAKI-2 RCC cells did not significantly influence RA associated antiproliferative actions. PMID: 16215318
- MycN binds to the promoter of CRABP-II and induces CRABP-II transcription directly in neuroblastoma. PMID: 16912187
- Results describe the structure of apo-wild type (WT) CRABPII at 1.35 A and show that apo- and holo-CRABPII share very similar structures. PMID: 16979656
- AP2 factors regulate CRABPII expression in human mammary epithelial cells and breast cancer cells PMID: 17187826
- results show that the CRABP2 gene is associated with increased plasma LDL-C concentrations. Carriers of the C allele had significantly higher LDL-C in healthy males, HIV-infected patients, and patients with familial hypercholesterolemia PMID: 17484622
- Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
- MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development. PMID: 18955045
- Derangement/lack of a critical factor necessary for RARalpha function induces epigenetic repression of a RA-regulated gene network downstream of RARalpha, with major pleiotropic biological outcomes. PMID: 19173001
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亞細胞定位：Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
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蛋白家族：Calycin superfamily, Fatty-acid binding protein (FABP) family
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