CDKN2C Recombinant Monoclonal Antibody
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中文名稱：CDKN2C Recombinant Monoclonal Antibody
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貨號：CSB-RA580611A0HU
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規格：￥1320
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圖片：
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Overlay Peak curve showing jurkat cells stained with CSB-RA580611A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6), CDKN2C, CDKN6
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反應種屬：Human
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免疫原：A synthesized peptide from human CDKN2C protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：2D11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
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基因功能參考文獻：
- Low P18 expression is associated with multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. PMID: 29134609
- Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
- genetic association studies in population in Houston TX: Data suggest that CDKN2C copy number variations are associated with sporadic medullary thyroid carcinoma; these associations include presence of distant metastasis at presentation and decreased overall survival. PMID: 27610696
- CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders. PMID: 27750397
- Our study suggests that p18 is a limiting factor for the noncanonical HSC differentiation path in lymphoid lineages. PMID: 27287689
- CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia. PMID: 27888400
- DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis PMID: 26350239
- Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors). PMID: 26740620
- Mutations in CDKN2C is associated with sporadic parathyroid adenoma. PMID: 24127162
- Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool. PMID: 22896639
- up-regulated HULC promotes proliferation of hepatoma cells through suppressing p18 PMID: 22685290
- Data indicate that the role of CDKN2C in the adverse outcome of cases with hemizygous deletion was less certain. PMID: 21994415
- results demonstrate for the first time that N-Myc is a downstream target of RET2A signaling, and propose that induction of N-Myc by RET2A is a key step leading to lower p18 levels during MEN2A tumorigenesis PMID: 21112821
- conclude that E2F proteins and Sp1 play an important role in the control of p18 expression PMID: 12077144
- Deletions in the CDKN2C locus and hypermethylation in the CDKN2C promoter region play a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
- p18INK4c may function as a tumor suppressor in Hodgkin lymphoma, and inactivation may contribute to cell cycle deregulation and defective terminal differentiation of the Reed-Sternberg cells. PMID: 14645011
- protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c) PMID: 15107819
- p18(INK4C) loss may contribute to medulloblastoma formation in children PMID: 16260494
- oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
- NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. PMID: 18642058
- deletions of CDKN2C are important in the progression and clinical outcome of myeloma PMID: 18829482
- P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma PMID: 18942719
- Purpose was to investigate genetic alterations of CDKN2C gene in 38 pituitary adenomas. The absence of CDKN2C protein was correlated with LOH of the CDKN2C locus on chromosome 1 and with methylation of the CDKN2C promoter. PMID: 18973139
- The down-regulation of p18(INK4C) expression may contribute to the tumorigenesis of pituitary adenomas. PMID: 19401813
- p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068
- Results identified a molecular basis for CDK inhibitors to exert an antitumor effect in p18-deficient cancers and support the clinical use of CDK inhibitors. PMID: 19509251
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蛋白家族：CDKN2 cyclin-dependent kinase inhibitor family
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組織特異性：Highest levels found in skeletal muscle. Also found in pancreas and heart.
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數據庫鏈接：
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