CCR8 Recombinant Monoclonal Antibody
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中文名稱：CCR8重組抗體
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貨號：CSB-RA004847MA4HU
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規(guī)格：￥1320
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圖片：
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Untransfected HEK293T cells surface(green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry. -
Untransfected CHO-K1 cells surface (green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA004847MA4HU是針對人CCR8蛋白研發(fā)的重組單克隆抗體，靶向該趨化因子受體的特異性表位。CCR8作為G蛋白偶聯(lián)受體家族成員，在調(diào)節(jié)性T細(xì)胞（Treg）及腫瘤相關(guān)巨噬細(xì)胞中高表達(dá)，通過介導(dǎo)CCL1等配體信號傳導(dǎo)參與免疫抑制微環(huán)境的形成，在腫瘤免疫逃逸和炎癥性疾病中發(fā)揮重要作用。本抗體經(jīng)流式細(xì)胞術(shù)（FC）嚴(yán)格驗證，展示出優(yōu)異的抗原結(jié)合能力與批次間穩(wěn)定性，適用于體外細(xì)胞表面標(biāo)志物檢測。科研領(lǐng)域可用于：1）腫瘤微環(huán)境中免疫抑制性細(xì)胞的表型分析；2）Treg細(xì)胞功能調(diào)控機(jī)制研究；3）構(gòu)建CCR8相關(guān)信號通路的體外模型；4）評估免疫檢查點調(diào)控藥物對CCR8+細(xì)胞亞群的影響。該產(chǎn)品采用重組表達(dá)技術(shù)生產(chǎn)，具有高純度、低內(nèi)毒素特性，適用于流式細(xì)胞分析等基礎(chǔ)研究中的細(xì)胞表面蛋白檢測需求。
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Uniprot No.：
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基因名：
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別名：C C chemokine receptor type 8 antibody; C C CKR 8 antibody; C C motif chemokine receptor 8 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC chemokine receptor 8 antibody; CC chemokine receptor CHEMR1 antibody; CC chemokine receptor type 8 antibody; CC CKR 8 antibody; CC-CKR-8 antibody; CCR 8 antibody; CCR-8 antibody; Ccr8 antibody; CCR8 protein antibody; CCR8-L antibody; CCR8_HUMAN antibody; CDw198 antibody; CDw198 antigen antibody; Chemokine (C C motif) receptor 8 antibody; Chemokine (C C) receptor 8 antibody; Chemokine (C C) receptor like 2 antibody; Chemokine (CC motif) receptor 8 antibody; Chemokine (CC) receptor 8 antibody; Chemokine (CC) receptor like 1 antibody; Chemokine (CC) receptor like 2 antibody; Chemokine C C motif receptor 8 antibody; Chemokine C C receptor 8 antibody; Chemokine CC motif receptor 8 antibody; Chemokine CC receptor 8 antibody; Chemokine receptor 8 antibody; Chemokine receptor like 1 antibody; Chemokine receptor-like 1 antibody; CKR L1 antibody; CKR-L1 antibody; CKRL 1 antibody; CKRL1 antibody; CMKBR 8 antibody; CMKBR L2 antibody; CMKBR8 antibody; CMKBRL 2 antibody; CMKBRL2 antibody; CY 6 antibody; CY6 antibody; GPR CY6 antibody; GPR-CY6 antibody; GPRCY6 antibody; MGC123958 antibody; MGC123959 antibody; MGC129966 antibody; MGC129973 antibody; TER 1 antibody; TER1 antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human CCR8 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1，lambda 2
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純化方式：Affinity-chromatography
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克隆號：10A9
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：FC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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基因功能參考文獻(xiàn)：
- Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
- Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
- High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
- findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
- Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
- CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
- Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
- CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
- Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
- There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
- CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
- found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
- CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
- Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
- The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
- the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
- CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
- The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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