src Antibody, Biotin conjugated

^{Rare Species}

說明書

中文名稱：

src兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA24479D0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) src Polyclonal antibody
Uniprot No.：

Q1JPZ3
基因名：

src
別名：

src antibody; Proto-oncogene tyrosine-protein kinase Src antibody; EC 2.7.10.2 antibody; Proto-oncogene c-Src antibody; pp60c-src antibody; p60-Src antibody
宿主：

Rabbit
反應種屬：

Zebrafish
免疫原：

Recombinant Zebrafish Proto-oncogene tyrosine-protein kinase Src protein (2-146AA)
免疫原種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each src kinase is very difficult. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of src to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process. When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including ptk2/fak1 and paxillin (pxn). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Involved in anchorage-independent cell growth.
基因功能參考文獻：
1. Src-Tks5 pathway is required for neural crest cell migration during embryonic development PMID: 21799874
亞細胞定位：

Cell membrane; Lipid-anchor. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, perinuclear region.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
組織特異性：

Widely expressed.
數據庫鏈接：

KEGG: dre:325084

STRING: 7955.ENSDARP00000093618

UniGene: Dr.2731

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