nrdA Antibody, HRP conjugated

^{Rare Species}

說明書

中文名稱：

nrdA兔多克隆抗體, HRP偶聯
貨號：

CSB-PA355522HB01EVN
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Escherichia coli nrdA Polyclonal antibody
Uniprot No.：

P00452
基因名：

nrdA
別名：

nrdA antibody; dnaF antibody; b2234 antibody; JW2228 antibody; Ribonucleoside-diphosphate reductase 1 subunit alpha antibody; EC 1.17.4.1 antibody; Protein B1 antibody; Ribonucleoside-diphosphate reductase 1 R1 subunit antibody; Ribonucleotide reductase 1 antibody
宿主：

Rabbit
反應種屬：

Escherichia coli
免疫原：

Recombinant Escherichia coli Ribonucleoside-diphosphate reductase 1 subunit alpha protein (1-761AA)
免疫原種屬：

Escherichia coli
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
基因功能參考文獻：
1. Elimination of 6 helicases lowered NrdA production further, whereas overexpression of any RNA helicase partially reversed the downregulation. UV stress completely reversed down-regulation of NrdA production PMID: 26574793
2. The present results identifying a large, new set of E. coli mutator strains with mutations of nrdAB ribonucleotide reductase(RNR)confirm the important control that RNR exerts on the cellular mutation rate and provide novel insights into the RNR feedback regulatory mechanisms. PMID: 22417940
3. RNR101 is unstable at 42 degrees C ; its degradation is prevented by rifampicin; inactivation of DnaA protein by allows chromosome replication in absence of rifampicin and suppresses nucleoid segregation and cell division defects seen in nrdA101 mutant at 42 degrees C PMID: 21527473
4. The report three independent methods that establish that Y(356) is the predominant location (85-90%) of the radical, with the remaining 10-15% delocalized onto Y(731) and Y(730) in alpha2. PMID: 21967342
5. The authors propose that RecA is required to maintain the integrity of the reversed forks in the nrdA101 mutant under certain restrictive conditions, supporting the relationship between DNA replication and recombination enzymes. PMID: 21441507
6. The authors show that the binding of DnaA on the NrdAB promoter can either activate or repress transcription as a function of its concentration and its nucleotide-bound state. PMID: 20487274
7. analysis of key residues in the dimerization process of ribonucleotide reductase protein R1 PMID: 15699052
8. There is an indirect relationship between NDP reductase and the chromosome segregation machinery through the maintenance of the proposed replication hyperstructure. PMID: 17124544
9. it is proposed that an altered NDP reductase, as a component of the replication machinery, impairs the progression of the replication fork, contributing to the lengthening of the C period in the nrdA101 mutant at the permissive temperature PMID: 17322311
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蛋白家族：

Ribonucleoside diphosphate reductase large chain family
數據庫鏈接：

KEGG: ecj:JW2228

STRING: 316385.ECDH10B_2393

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