lpxC Antibody

^{Rare Species}

中文名稱：

lpxC兔多克隆抗體
貨號：

CSB-PA358910HA01ENV
規格：

￥440
其他：

產品詳情
產品評價
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問答及客戶評論
靶點詳情

產品詳情

產品描述：

lpxC polyclonal antibody CSB-PA358910HA01ENV was produced in the rabbit immunized by using the Recombinant Escherichia coli UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase protein (1-305AA) as the immunogen. The target protein lpxC plays a critical role in catalyzing the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Due to its important role in lipid A synthesis, LpxC is an attractive target for the development of new antibacterial agents to treat Gram-negative infections.
This Rabbit anti-Escherichia coli (strain K12) lpxC Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the lpxC proteins of Escherichia coli-origin and may be used to detect the endogenous levels of lpxC protein.
產品名稱：

Rabbit anti-Escherichia coli lpxC Polyclonal antibody
Uniprot No.：

P0A725
基因名：

lpxC
別名：

lpxC antibody; asmB antibody; envA antibody; b0096 antibody; JW0094 antibody; UDP-3-O-acyl-N-acetylglucosamine deacetylase antibody; UDP-3-O-acyl-GlcNAc deacetylase antibody; EC 3.5.1.108 antibody; Protein EnvA antibody; UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase antibody
宿主：

Rabbit
反應種屬：

Escherichia coli
免疫原：

Recombinant Escherichia coli UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase protein (1-305AA)
免疫原種屬：

Escherichia coli

標記方式：

Non-conjugated

本頁面中的產品，lpxC Antibody (CSB-PA358910HA01ENV)，的標記方式是Non-conjugated。對于lpxC Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA358910HB01ENV	lpxC Antibody, HRP conjugated	ELISA
FITC	CSB-PA358910HC01ENV	lpxC Antibody, FITC conjugated
Biotin	CSB-PA358910HD01ENV	lpxC Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

NaCl+NaN3
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

問答及客戶評論

■ 客戶評論

Western blot review for CD146 Monoclonal Antibody

Tested application: WB, IP
Test sample&species: E.coli
Primary antibody dilution ratio: 1:1000
Review: The experimental results are OK, but there are bands, which may be related to polyclonal antibodies. Also used for IP, although the manual is only ELISA.

靶點詳情

功能：

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
基因功能參考文獻：
1. analysis of mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis PMID: 23316051
2. the active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions PMID: 20709752
3. The C-terminus of LpxC contains a signal sequence necessary for FtsH-dependent degradation. PMID: 16420369
4. potency of LpxC inhibitors in vitro can be altered by assay conditions and development of inhibitorsand that the metal ion status of LpxC in vivo may influence the effectiveness of LpxC inhibitors as antibiotics. PMID: 17144651
5. Functions of LpxC active site residues have been classified on the basis of changes in steady-state turnover and product binding affinity; side chains are identified that enhance and destabilize product affinity as well as enhance catalytic efficiency. PMID: 17176046
6. A C-terminal tail of about 20 amino acids length is required for proteolysis of LpxC by FtsH PMID: 17651755
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蛋白家族：

LpxC family
數據庫鏈接：

KEGG: ecj:JW0094

STRING: 316385.ECDH10B_0078

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