Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 2 (Apba2)

說明書

中文名稱：

Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 2(Apba2)
貨號：

001887MO
規(guī)格：
其他：

產品詳情
產品評價
靶點詳情

產品詳情

Uniprot No.：

P98084
基因名：

Apba2
別名：

Apba2; X11lAmyloid-beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2
免疫原種屬：

Mus musculus (Mouse)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
基因功能參考文獻：
1. Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues. PMID: 27268412
2. Mints 1 and 2 perform redundant synaptic functions and have a role in regulation of gamma-aminobutyric acid release PMID: 12547917
3. X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice PMID: 15347685
4. APPPS1 mice are well suited for studying therapeutic strategies and the pathomechanism of amyloidosis by cross-breeding to other genetically engineered mouse models. PMID: 16906128
5. X11L suppresses the amyloidogenic but not amyloidolytic processing of APP in regions of the brain such as the hippocampus, which express significant levels of X11L. PMID: 17032642
6. shuttled between the cytoplasm and nucleus, the former more effectively than the latter; leptomycin B (LMB) induced substantial nuclear accumulation of EGFP-X11L PMID: 18201694
7. X11s associate primarily with APP molecules that are outside of DRM, that the dissociation of APP-X11/X11L complexes leads to entry of APP into DRM, and that cleavage of uncomplexed APP by BACE within DRM PMID: 18845544
8. This study suggested X11L is involved in the development of neuronal circuits that contribute to conflict resolution. PMID: 19420255
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組織特異性：

Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.
數(shù)據(jù)庫鏈接：

KEGG: mmu:11784

STRING: 10090.ENSMUSP00000032732

UniGene: Mm.4657