Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 5 (Fmo5)

說明書

中文名稱：

小鼠Fmo5重組蛋白
貨號：

008751MO
規(guī)格：
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P97872
基因名：

Fmo5
別名：

Fmo5Dimethylaniline monooxygenase [N-oxide-forming] 5; EC 1.14.13.8; Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5
免疫原種屬：

Mus musculus (Mouse)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應(yīng)用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
基因功能參考文獻：
1. Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet. PMID: 28646079
2. The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging. PMID: 26049045
3. The functional activity of Fmo5 was determined. PMID: 17721934
亞細胞定位：

Microsome membrane. Endoplasmic reticulum membrane.
蛋白家族：

FMO family
組織特異性：

Expressed in liver (at protein level). Expressed in the mucosal epithelium of the gastrointestinal tract.
數(shù)據(jù)庫鏈接：

KEGG: mmu:14263

STRING: 10090.ENSMUSP00000029729

UniGene: Mm.385180