Recombinant Mouse ALK tyrosine kinase receptor (Alk), partial

說明書

中文名稱：

Recombinant Mouse ALK tyrosine kinase receptor(Alk) ,partial
貨號：

001606MO
規格：
其他：

產品詳情
產品評價
靶點詳情

產品詳情

Uniprot No.：

P97793
基因名：

Alk
別名：

AlkALK tyrosine kinase receptor; EC 2.7.10.1; Anaplastic lymphoma kinase; CD antigen CD246
免疫原種屬：

Mus musculus (Mouse)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis.
基因功能參考文獻：
1. Anaplastic lymphoma kinase (ALK) is a novel regulator of NLRP3 inflammasome activation in macrophages. Mechanically, ALK-mediated NF-kappaB activation was required for the priming step of NLRP3 upregulation, whereas ALK-mediated lipid peroxidation contributed to the sensing step of NLRP3-NEK7 complex formation. PMID: 29723525
2. NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development. PMID: 27604320
3. These data support an important role for the p55gamma subunit of PI3K in ALK-induced cell migration during brain development PMID: 27322022
4. Increased ETS exposure was closely associated with EGFR mutations in female never-smokers with NSCLC in the expanded multinational cohort. However, the association of ETS and ALK rearrangements in never-smokers with NSCLC was not significant. PMID: 28433570
5. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol dependence in humans and behavioral responses to ethanol in mice. PMID: 26752591
6. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells. PMID: 26829053
7. ALK inhibitor alectinib inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. PMID: 28455243
8. Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice. PMID: 26946429
9. An oral anaplastic lymphoma kinase (ALK) inhibitor. PMID: 26361725
10. ALK knock out male mice exhibit hypogonadotropic hypogonadism. PMID: 25955180
11. Ethanol activates ALK (and MDK) signaling in the brain which regulates behaviors related to alcohol abuse. PMID: 26206265
12. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice. PMID: 24811761
13. Mutations in the ALK gene is associated with neuroblastoma. PMID: 24811913
14. Th-MYCN genetically-engineered murine models of neuroblastoma using MRI, we have identified a marked ALK(F1174L)-driven vascular phenotype. PMID: 24667968
15. Reduced ALK1 expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts. PMID: 24594380
16. findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma PMID: 22789543
17. KLC1-ALK is the first novel oncogenic fusion identified using only formalin-fixed paraffin-embedded tissue tissues PMID: 22347464
18. In hippocampus, Alk and Ltk (leukocyte tyrosine kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest enhanced performance in spatial memory and reduced neurogenesis in Alk mutant/knockout mice. PMID: 22079349
19. High anaplastic lymphoma kinase is associated with angiogenesis in neuroblastoma. PMID: 21829174
20. novel ALK point mutations possessed tumorigenic effects mainly through hyperphosphorylation of Y1604 and activation of downstream oncogenic signaling. PMID: 21847362
21. Alk plays an evolutionary conserved role in ethanol-related behaviors PMID: 21799923
22. Transcription of anaplastic lymphoma kinase (Alk) is repressed by LMO4 in the striatum and Alk promotes the development of cocaine sensitization and conditioned place preference. PMID: 21976498
23. data show that neoplastic mast cells (MC) express IL-9 receptors, that IL-9 and NPM-ALK upregulate MC-production in vivo, and that both'hits' act in concert to induce a mastocytosis-like disease in mice PMID: 21297223
24. Cellular transformation is not an inevitable consequence of NPM-ALK activity but is combated by p53 and Rb. PMID: 21423761
25. ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma. PMID: 20190816
26. A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells. PMID: 11919185
27. role of anaplastic lymphoma kinase and pleiotrophin signaling in apoptosis PMID: 12107166
28. midkine binds to ALK and has a role in signal transduction for cell growth and survival PMID: 12122009
29. overexpression in fused forme with NPM induced different types of malignant lymphomas in IL-9 transgenic mice PMID: 12555065
30. Alk chimera is endocytosis impaired. PMID: 14691459
31. ALK receptor tyrosine kinase has roles promoting cell growth and neurite outgrowth PMID: 15226403
32. ALK has a proapoptotic activity in the absence of ligand, whereas it is antiapoptotic in the presence of its ligand and when the kinase is intrinsically activated. PMID: 16880530
33. Alk is an effective oncoantigen for lymphoma vaccination. PMID: 18469826
34. The expression of the dual specificity phosphatase CDC25A, is deregulated in Ba/F3 cells expressing the oncogenic protein NPM/ALK and in human cell lines derived from NPM/ALK-positive anaplastic large cell lymphomas. PMID: 19305144
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
組織特異性：

Mainly expressed in central nervous system (CNS) and other parts of the brain such as the paraventricular nucleus (PVN) of the hypothalamus. Expression is also found in peripheral nervous systems, eye, nasal epithelium, olfactory nerve, tongue, skin, tiss
數據庫鏈接：

KEGG: mmu:11682

STRING: 10090.ENSMUSP00000083840

UniGene: Mm.311854