Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 3 (Fmo3)
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中文名稱:小鼠Fmo3重組蛋白
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貨號:008749MO
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規格:
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其他:
產品詳情
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Uniprot No.:
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基因名:Fmo3
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別名:Fmo3Dimethylaniline monooxygenase [N-oxide-forming] 3; EC 1.14.13.8; EC 1.14.14.73; Dimethylaniline oxidase 3; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase; EC 1.14.13.148
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免疫原種屬:Mus musculus (Mouse)
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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應用說明:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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儲存條件:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能:Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
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基因功能參考文獻:
- Diabetes induced the expression of both Fmo3 and ICAM expression and possible vascular impairment through enteric dysbiosis. Diabetes-induced Fmo3 and ICAM expression could be reversed by pJNK inhibition or by correcting enteric dysbiosis. PMID: 29851956
- The suppression of FMO3 metabolism related to reversible S-nitrosyl modifications of iNOS-derived NO in type 1 allergic mice. PMID: 28760731
- knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) confers protection against obesity in mice. PMID: 28636934
- FMO3 can contribute to the regulation of glucose metabolism in the liver by reducing lipid-induced endoplasmic reticulum stress and the expression of PEPCK, independently of insulin signal transduction. PMID: 26886171
- FMO3 is increased in obese/insulin resistant male mice and necessary for expression of FoxO1. PMID: 25849138
- Fmo3 expression and function plays a role in protecting the liver from acetaminophen-induced toxicity. PMID: 24973094
- a major role for FMO3 in modulating glucose and lipid homeostasis PMID: 25378658
- Report temporal changes in hepatic Fmo3 gene expression under different conditions all known to cause hepatic oxidative stress. PMID: 25193093
- Report selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in SCID mice. PMID: 22745333
- The functional activity of Fmo3 was determined. PMID: 17721934
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亞細胞定位:Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
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蛋白家族:FMO family
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組織特異性:Liver.
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數據庫鏈接:
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