Recombinant Dog T-cell surface glycoprotein CD4 (CD4), partial
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中文名稱：Recombinant Dog T-cell surface glycoprotein CD4(CD4),partial
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貨號：004935DO1
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規格：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4
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免疫原種屬：Canis familiaris (Dog) (Canis lupus familiaris)
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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應用說明：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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儲存條件：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
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基因功能參考文獻：
- Data suggest that in dogs, as in humans, CD4(+) CD25(+) FoxP3(+) Tregs may contribute to the pathogenesis of canine atopic dermatitis as indicated by an association between Treg frequency and disease severity PMID: 26748886
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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組織特異性：Expressed in macrophages and a subset of T lymphocytes.
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數據庫鏈接：
KEGG: cfa:403931
UniGene: Cfa.3673
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