beta-Spec Antibody

^{Rare Species}

說明書

中文名稱：

beta-Spec兔多克隆抗體
貨號：

CSB-PA251598XA01DLU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: recombinant protein
All lanes: beta-Spec Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35.4 kDa
Observed band size: 35.4 kDa
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q00963
基因名：

beta-Spec
別名：

Spectrin beta chain beta-Spec Spec-b CG5870
反應種屬：

Drosophila melanogaster (Fruit fly)
免疫原：

Recombinant Drosophila melanogaster (Fruit fly) beta-Spec protein (1-271aa)
免疫原種屬：

Drosophila melanogaster (Fruit fly)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Affinity-chromatography
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.
基因功能參考文獻：
1. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the b-spectrin mutations and the loss of the Hippo signaling activity phenotype. PMID: 25589787
2. Model in which alphabeta-spectrin directly couples lipid uptake at the plasma membrane to lipid droplet growth in the cytoplasm. In contrast, strong overexpression of beta-spectrin caused fat body atrophy and larval lethality. PMID: 24037266
3. Data show that DAnk2-binding is critical for beta spectrin function in vivo. PMID: 20573981
4. Spectrin may be an active partner in the stabilization of polarized membrane domains PMID: 14734656
5. Presynaptic spectrin functions as an essential presynaptic scaffold that may link synaptic cell adhesion with the stabilization of the underlying microtubule cytoskeleton. PMID: 15916948
6. Brush border spectrin is required for early endosome recycling. PMID: 16537648
7. At the Drosophila neuromuscular junction postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged. PMID: 17088429
8. beta-Spectrin is required in neurons for proper midline axon guidance in the embryonic CNS. PMID: 17121810
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
蛋白家族：

Spectrin family
數據庫鏈接：

KEGG: dme:Dmel_CG5870

STRING: 7227.FBpp0074228

UniGene: Dm.7022

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