ZDHHC9 Antibody
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中文名稱：ZDHHC9兔多克隆抗體
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貨號(hào)：CSB-PA020260
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of 293T cells using DHHC-9 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ZDHHC9
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別名：ZDHHC9; CXorf11; ZDHHC10; ZNF379; ZNF380; CGI-89; UNQ261/PRO298; Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9; DHHC-9; DHHC9; Zinc finger protein 379; Zinc finger protein 380
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the C-terminal region of Human DHHC-9.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
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基因功能參考文獻(xiàn)：
- The results demonstrate that a mutation in a ZDHHC9 mutation impacts upon white matter organization across the whole-brain, but also shows regionally specific effects, according to variation in gene expression. PMID: 28168288
- studies suggest that ZDHHC9 may serve as a safe and effective target for developing therapies against NRAS-driven cancers PMID: 26493479
- Data demonstrate that ZDHHC9 mutations are associated with reductions in cortical thickness and white matter microstructural integrity, particularly in regions and networks known to contribute to language function. PMID: 27747153
- De novo ZDHHC9 mutation was identified in a patient with X-linked intellectual disability. PMID: 28687527
- Report demonstrated that MMSA-1 is specifically expressed in multiple myeloma patients and its upregulation is associated with unfavorable clinical features and poor prognosis. PMID: 26493349
- ZDHHC9 gene mutation is associated with Lujan-Fryns syndrome. PMID: 26358559
- Two missense mutation, R148W and P150S,of zDHHC9, affecting the autopalmitoylation is associated with the X-linked intellectual disability. PMID: 24811172
- Data indicate that sp-Erf2/zDHHC9 palmitoylates Ras proteins in a highly selective manner in the trans-Golgi compartment to facilitate PM targeting via the trans-Golgi network, a role that is most certainly critical for Ras-driven tumorigenesis. PMID: 24248599
- MMSA-1 may play a pivotal role in multiple myeloma proliferation and osteolysis destruction. PMID: 22230506
- Studies indicate that mutations in DHHC9 were associated with X-linked mental retardation. PMID: 21388813
- Data show that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes. PMID: 16000296
- DHHC9 is a gastrointestinal-related protein highly expressed in microsatellite stable colorectal cancers. PMID: 17519897
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相關(guān)疾病：Mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ)
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亞細(xì)胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
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蛋白家族：DHHC palmitoyltransferase family, ERF2/ZDHHC9 subfamily
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組織特異性：Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes.
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數(shù)據(jù)庫(kù)鏈接：
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