ZC3H14 Antibody, FITC conjugated
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中文名稱：ZC3H14兔多克隆抗體, FITC偶聯
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貨號：CSB-PA740793LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZC3H14 Polyclonal antibody
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Uniprot No.：
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基因名：ZC3H14
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別名：FLJ11806 antibody; Mammalian suppressor of tau pathology-2 antibody; MGC26892 antibody; MSUT-2 antibody; Nuclear protein UKp68 antibody; NY REN 37 antibody; NYREN 37 antibody; Renal carcinoma antigen NY REN 37 antibody; Renal carcinoma antigen NY-REN-37 antibody; Renal carcinoma antigen NYREN 37 antibody; suppressor of tau 2, C. elegans, homolog of antibody; SUT2 antibody; UKp68 antibody; ZC3H14 antibody; ZC3HE_HUMAN antibody; Zinc finger CCCH domain-containing protein 14 antibody; Zinc finger CCCH type containing 14 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zinc finger CCCH domain-containing protein 14 protein (176-306AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
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基因功能參考文獻：
- ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus. PMID: 27563065
- we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies PMID: 24671764
- report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein PMID: 21734151
- MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation. PMID: 21355046
- New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders. PMID: 20658987
- these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins PMID: 17630287
- multiple transcripts encoding several ZC3H14 isoforms exist in vivo PMID: 19303045
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相關疾病：Mental retardation, autosomal recessive 56 (MRT56)
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亞細胞定位：Nucleus speckle.; [Isoform 1]: Nucleus speckle.; [Isoform 3]: Nucleus speckle.; [Isoform 6]: Cytoplasm.
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蛋白家族：ZC3H14 family
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組織特異性：Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.
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數據庫鏈接：
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